Evidence map›Paper›PMID 34751943›Full record

ReviewCA: a cancer journal for clinicians2022

Integrative oncology: Addressing the global challenges of cancer prevention and treatment.

Jun J Mao, Geetha Gopalakrishna Pillai, Carlos Jose Andrade, Jennifer A Ligibel, Partha Basu, Lorenzo Cohen, Ikhlas A Khan, Karen M Mustian, Rammanohar Puthiyedath, Kartar Singh Dhiman and 6 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CA: a cancer journal for clinicians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 220 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06118853 nacompletednot on this mapstarted 2023, after this paper: background citation

Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation at the Hospital Israelita Albert Einstein

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2023 to 2025Enrolled35ConditionsHematopoietic Stem Cell Transplantation, Bone Marrow TransplantationArmsyoga or gentle massage plus standard treatment for HSCT
NCT06328751 narecruitingnot on this mapstarted 2024, after this paper: background citation

Study With Cancer Patients at the CECON Foundation's Pain Therapy and Palliative Care Service: Meditation With Immersive Virtual Reality for Pain Relief

TypeinterventionalSponsorEmily Santos MontarroyosRan2024 to 2027Enrolled129ConditionsCancer Pain, Quality of Life, Palliative MedicineArmsCase group, Active control group, Passive control group
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  9. Influence of melatonin supplementation on cancer-related fatigue: a meta-analysis of randomized controlled trials.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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  17. Massage therapy significantly improves cancer-related fatigue in cancer patients: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  20. The impact of integrative medicine on quality of life in patients with diabetes mellitus and cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial

160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jun J MaoBendheim Integrative Medicine Center, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-9229-0380
Geetha Gopalakrishna PillaiTraditional, Complementary and Integrative Medicine Unit, Service Delivery and Safety Department, World Health Organization, Geneva, Switzerland.
Carlos Jose AndradeBrazilian National Cancer Institute, Rio de Janeiro, Brazil.
Jennifer A LigibelLeonard P. Zakim Center for Integrative Therapies and Healthy Living, Dana-Farber Cancer Institute, Boston, Massachusetts.
Partha BasuInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Lorenzo CohenIntegrative Medicine Program, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ikhlas A KhanNational Center for Natural Products Research, University of Mississippi, Jackson, Mississippi.
Karen M MustianWilmot Cancer Institute, Department of Surgery, University of Rochester Medical Center, Rochester, New York.
Rammanohar PuthiyedathAmrita Vishwa Vidyapeetham University, Amritapuri, Kerala, India.
Kartar Singh DhimanCentral Council for Research in Ayurvedic Sciences, New Delhi, India.
Lixing LaoVirginia University of Integrative Medicine, Fairfax, Virginia.
Ricardo GhelmanBrazilian Academic Consortium for Integrative Health, University of São Paulo, São Paulo, Brazil.
Paulo Cáceres GuidoPharmacokinetics and Research in Clinical Pharmacology and Integrative Medicine Group, Garrahan Pediatric Hospital, Buenos Aires, Argentina.ORCID 0000-0002-9747-4960
Gabriel LopezIntegrative Medicine Program, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Daniel F Gallego-PerezTraditional, Complementary, and Integrative Medicine Network of the Americas, São Paulo, Brazil.
Luis Alejandro SalicrupCenter for Global Health and Office of Cancer Complementary and Alternative Medicine, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Herbal Education and Research in Oncology Program made possible by the Laurance S. Rockefeller FundNCI NIH HHS P30 CA008748NCI NIH HHS UG1 CA189961World Health Organization 001
6 · The paper itself

Abstract

The increase in cancer incidence and mortality is challenging current cancer care delivery globally, disproportionally affecting low- and middle-income countries (LMICs) when it comes to receiving evidence-based cancer prevention, treatment, and palliative and survivorship care. Patients in LMICs often rely on traditional, complementary, and integrative medicine (TCIM) that is more familiar, less costly, and widely available. However, spheres of influence and tensions between conventional medicine and TCIM can further disrupt efforts in evidence-based cancer care. Integrative oncology provides a framework to research and integrate safe, effective TCIM alongside conventional cancer treatment and can help bridge health care gaps in delivering evidence-informed, patient-centered care. This growing field uses lifestyle modifications, mind and body therapies (eg, acupuncture, massage, meditation, and yoga), and natural products to improve symptom management and quality of life among patients with cancer. On the basis of this review of the global challenges of cancer control and the current status of integrative oncology, the authors recommend: 1) educating and integrating TCIM providers into the cancer control workforce to promote risk reduction and culturally salient healthy life styles; 2) developing and testing TCIM interventions to address cancer symptoms or treatment-related adverse effects (eg, pain, insomnia, fatigue); and 3) disseminating and implementing evidence-based TCIM interventions as part of comprehensive palliative and survivorship care so patients from all cultures can live with or beyond cancer with respect, dignity, and vitality. With conventional medicine and TCIM united under a cohesive framework, integrative oncology may provide citizens of the world with access to safe, effective, evidence-informed, and culturally sensitive cancer care.

Indexed as

Complementary TherapiesIntegrative MedicineIntegrative OncologyNeoplasmsDelivery of Health CareHumansQuality of Lifealternativeand integrative medicinecancer preventioncomplementaryglobal healthhealth policysurvivorship

Identifiers

PMID34751943
PMCPMC13183357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.