Evidence map›Paper›PMID 34751889›Full record

ReviewMolecular neurobiology2022

Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer's Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside.

Vaibhav Walia, Deepak Kaushik, Vineet Mittal, Kuldeep Kumar, Ravinder Verma, Jatin Parashar, Rokeya Akter, Md Habibur Rahman, Saurabh Bhatia, Ahmed Al-Harrasi and 4 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Precision USPIO-PEG-SLeInternational journal of nanomedicine · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 5 countries.

Vaibhav WaliaSGT College of Pharmacy, SGT University, Gurugram, Haryana, India.
Deepak KaushikDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Vineet MittalDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Kuldeep KumarDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Ravinder VermaDepartment of Pharmacy, School of Medical and Allied Sciences, G.D. Goenka University, Gurugram, 122103, India.
Jatin ParasharDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India.
Rokeya AkterDepartment of Pharmacy, Jagannath University, Sadarghat, Dhaka, 1100, Bangladesh.
Md Habibur RahmanDepartment of Pharmacy, Southeast University, Banani, Dhaka, 1213, Bangladesh. pharmacisthabib@gmail.com.ORCID http://orcid.org/0000-0001-6099-5693
Saurabh BhatiaSchool of Health Science University of Petroleum and Energy Studies, Dehrandun, Uttarkhand, 248007, India.
Ahmed Al-HarrasiNatural & Medical Sciences Research Center, University of Nizwa, 616 Birkat Al Mouz, P.O. Box 33, Nizwa, Oman.
Chenmala KarthikaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, The Nilgiris, Ooty, 643001, Tamil Nadu, India.
Tanima BhattacharyaCollege of Chemistry & Chemical Engineering, Hubei University, Wuhan, 430062, China.
Hitesh ChopraChitkara College of Pharmacy, Chitkara University, Punjab, 140401, India.
Ghulam Md AshrafPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Maharshi Dayanand University · INUniversity of Nizwa · OMChandigarh University · INChitkara University · INGD Goenka University · INHubei University · CNJagannath University · BDJSS Academy of Higher Education and Research · INKing Abdulaziz University · SAShree Guru Gobind Singh Tricentenary University · INSoutheast University · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is considered the sixth leading cause of death in elderly patients and is characterized by progressive neuronal degeneration and impairment in memory, language, etc. AD is characterized by the deposition of senile plaque, accumulation of fibrils, and neurofibrillary tangles (NFTs) which are responsible for neuronal degeneration. Amyloid-β (Aβ) plays a key role in the process of neuronal degeneration in the case of AD. It has been reported that Aβ is responsible for the production of reactive oxygen species (ROS), depletion of endogenous antioxidants, increase in intracellular Ca

Indexed as

Alzheimer DiseaseAnimalsAntioxidantsBrainHumansMitochondriaNeuroprotective AgentsOxidative StressReactive Oxygen SpeciesAntioxidantsNeuroprotective AgentsReactive Oxygen SpeciesAlzheimer’s diseaseAmyloid betaAntioxidantsEtcFree radicalsNeurodegenerationReactive oxygen species

Identifiers

PMID34751889
OpenAlexW3213985502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.