Evidence map›Paper›PMID 34751867›Full record

ArticleJournal of autism and developmental disorders2022

Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs.

Basmah H Alfageh, Frank M C Besag, Le Gao, Tian-Tian Ma, Kenneth K C Man, Ian C K Wong, Ruth Brauer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Basmah H AlfagehSchool of Pharmacy, University College London, London, UK.ORCID http://orcid.org/0000-0003-3051-9017
Frank M C BesagSchool of Pharmacy, University College London, London, UK.ORCID http://orcid.org/0000-0002-4530-7933
Le GaoCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Tian-Tian MaSchool of Pharmacy, University College London, London, UK.
Kenneth K C ManSchool of Pharmacy, University College London, London, UK.ORCID http://orcid.org/0000-0001-8645-1942
Ian C K WongSchool of Pharmacy, University College London, London, UK.ORCID http://orcid.org/0000-0001-8242-0014
Ruth BrauerSchool of Pharmacy, University College London, London, UK. r.brauer@ucl.ac.uk.ORCID http://orcid.org/0000-0001-8934-347X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients' chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74-2.19) compared to other psychotropics.

Indexed as

Antipsychotic AgentsAutism Spectrum DisorderCohort StudiesHumansPsychotropic DrugsRetrospective StudiesSeizuresAntipsychotic AgentsPsychotropic DrugsAntipsychotic medicationAutism spectrum disorder (ASD)Incident seizurePsychotropic medication

Identifiers

PMID34751867
PMCPMC9556371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.