Evidence map›Paper›PMID 34751838›Full record

ArticleDigestive diseases and sciences2022

A New Role for Conivaptan in Ulcerative Colitis in Mice: Inhibiting Differentiation of CD4

Dandan Dou, Yuge Ji, Junjie Zheng, Jingxin Li, Xiaolong Zhu, Shuhai Tang, Hongjuan Wang, Qin Li, Haiyan Jing

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Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Dandan DouDepartment of Pathology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, 250021, China.
Yuge JiDepartment of Physiology, School of Basic Medical Science, Shandong University, Jinan, China.
Junjie ZhengDepartment of Physiology, School of Basic Medical Science, Shandong University, Jinan, China.
Jingxin LiDepartment of Physiology, School of Basic Medical Science, Shandong University, Jinan, China.
Xiaolong ZhuDepartment of Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Shuhai TangDepartment of Anesthesiology, Qilu Hospital of Shandong University, Jinan, China.
Hongjuan WangDepartment of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Qin LiDepartment of Physiology, School of Basic Medical Science, Shandong University, Jinan, China.
Haiyan JingDepartment of Pathology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, 250021, China. haiyanjingbl@163.com.ORCID 0000-0003-0913-6898
Shandong University · CNShandong Provincial Hospital · CNQilu Hospital of Shandong University · CNSecond Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConivaptan, a nonselective antagonist of vasopressin receptors V1a and V2, is the first drug of this class to be used for treating euvolemic and hypervolemic hyponatremia. Recently, increasing evidence supports the involvement of vasopressin in immune responses.

aimsIn this study, we investigated the effect of conivaptan on the modulation of CD4

methodsThe expression of the V1a receptor on CD4

resultsWe found that CD4

conclusionsFor the first time, we report that conivaptan attenuated colitis by inhibiting the differentiation of CD4

Indexed as

ColitisColitis, UlcerativeAnimalsAntidiuretic Hormone Receptor AntagonistsBenzazepinesMiceTh1 CellsAntidiuretic Hormone Receptor AntagonistsBenzazepinesconivaptanCD4+T cellConivaptanInflammatory bowel diseaseTh1 cellV1a receptor

Identifiers

PMID34751838
OpenAlexW3213006104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.