Evidence map›Paper›PMID 34751837›Full record

ArticleDigestive diseases and sciences2022

Factors Associated with the Development of Gastrointestinal Symptoms in Patients Hospitalized with Covid-19.

Olga C Aroniadis, Xianling Wang, Tang Gong, Nauzer Forbes, Jeong Yun Yang, Andrew Canakis, Badih Joseph Elmunzer, Dhiraj Yadav, North American Alliance for the Study of Digestive Manifestations of Covid-19

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Diarrhea and Coronavirus Disease 2019 Infection.Gastroenterology clinics of North America · 2023
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Olga C AroniadisDivision of Gastroenterology, Renaissance School of Medicine at Stony Brook University, Stony Brook University Hospital, 101 Nicolls Road, Health Sciences Center T17-060, Stony Brook, NY, 11794, USA. olga.aroniadis@stonybrookmedicine.edu.ORCID 0000-0001-6501-0769
Xianling WangDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Tang GongDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Nauzer ForbesDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
Jeong Yun YangDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew CanakisDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC, USA.
Badih Joseph ElmunzerDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC, USA.
Dhiraj YadavDivision of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
North American Alliance for the Study of Digestive Manifestations of Covid-19
Medical University of South Carolina · USUniversity of Pittsburgh · USUniversity of Calgary · CAStony Brook School · USUniversity of Pittsburgh Medical Center · USIcahn School of Medicine at Mount Sinai · USStony Brook University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe most common symptoms of Covid-19 are respiratory; however, gastrointestinal symptoms are present in up to 50% of patients. We aimed to determine characteristics associated with the development of gastrointestinal symptoms in patients with Covid-19.

methodsA case-control study of adults hospitalized for Covid-19 was conducted across a geographically diverse alliance of 36 US and Canadian medical centers. Data were manually abstracted from electronic health records and analyzed using regression analyses to determine characteristics associated with any gastrointestinal symptoms and diarrhea specifically.

resultsOf 1406 patients, 540 (38%) reported at least one gastrointestinal symptom and 346 (25%) reported diarrhea. Older patients (≥ 80 years) had significantly lower rates of any gastrointestinal symptoms and diarrhea (vs. patients 18-79 years, OR 0.41, p < 0.01 and OR 0.43 p = 0.01, respectively), while those with IBS (OR 7.70, p = 0.02 and OR 6.72, p < 0.01, respectively) and on immunosuppressive therapy (OR = 1.56, p = 0.02) had higher rates of any gastrointestinal symptom and diarrhea. Patients with constitutional symptoms exhibited significantly higher rates (OR 1.91, p < 0.01), while those with pulmonary disease alone had lower rates of gastrointestinal symptoms (OR 0.23, p = 0.01). A significant interaction between constitutional symptoms and pre-existing pulmonary conditions was observed.

conclusionsSeveral patient- and disease-specific characteristics associate with gastrointestinal symptoms in patients with Covid-19. Knowledge of these may provide insights into associated pathophysiologic mechanisms, and help health care professionals provide targeted attention to reduce morbidity related to Covid-19.

Indexed as

COVID-19Gastrointestinal DiseasesAdultCanadaCase-Control StudiesDiarrheaHumansSARS-CoV-2CharacteristicsCovid-19Gastrointestinal symptoms

Identifiers

PMID34751837
PMCPMC8575674
OpenAlexW3213868073

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.