Evidence map›Paper›PMID 34751789›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

Temporal trends of TAVI treatment characteristics in high volume centers in Germany 2013-2020.

Victor Mauri, Mohamed Abdel-Wahab, Sabine Bleiziffer, Verena Veulemans, Alexander Sedaghat, Matti Adam, Georg Nickenig, Malte Kelm, Holger Thiele, Stephan Baldus and 1 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  4. Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Article
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  6. The implementation of a streamlined TAVI patient pathway across five European countries: BENCHMARK registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Observational
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  15. The influence of lipoprotein(a) on aortic valve calcification in patients undergoing transcatheter aortic valve replacement.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Victor MauriDepartment of Cardiology, Faculty of Medicine, Heart Center, University of Cologne, Cologne, Germany. victor.mauri@uk-koeln.de.ORCID http://orcid.org/0000-0003-2678-3501
Mohamed Abdel-WahabDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Sabine BleizifferDepartment of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany.
Verena VeulemansDepartment of Cardiology, Pulmonology and Vascular Medicine, Heart Center Düsseldorf, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Alexander SedaghatDepartment of Medicine II, Heart Center Bonn, University Hospital Bonn, Bonn, Germany.
Matti AdamDepartment of Cardiology, Faculty of Medicine, Heart Center, University of Cologne, Cologne, Germany.
Georg NickenigDepartment of Medicine II, Heart Center Bonn, University Hospital Bonn, Bonn, Germany.
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, Heart Center Düsseldorf, Heinrich Heine University, Medical Faculty, Düsseldorf, Germany.
Holger ThieleDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.
Stephan BaldusDepartment of Cardiology, Faculty of Medicine, Heart Center, University of Cologne, Cologne, Germany.
Tanja K RudolphDepartment of General and Interventional Cardiology, Heart- and Diabetes Center North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany.
University of Cologne · DEHeart and Diabetes Center North Rhine-Westphalia · DEHeinrich Heine University Düsseldorf · DELeipzig Heart Institute · DEUniversity Hospital Bonn · DE

Funding

deutsche forschungsgemeinschaft SFB TRR 259/1
6 · The paper itself

Abstract

objectiveTo assess temporal trends of patient baseline characteristics, risk profile and outcome of transcatheter aortic valve implantation (TAVI) between 2013 and 2020.

backgroundGuideline recommendations and increasing confidence in TAVI therapy may have changed the selection of TAVI patients.

methodsBaseline risk profile and VARC-2 outcome of 15,344 patients undergoing TAVI at 5 high volume centers in Germany over the time period 2013-2020 was analyzed.

resultsOver the 8 years, annual TAVI volumes more than doubled from 1071 in 2013 to 2996 in 2020. The baseline surgical risk estimated by the Society of Thoracic Surgeons (STS) score declined from 7.2 ± 6.2% to 4.6 ± 3.7% (P < 0.001) as a consequence of lower comorbidity burden, whereas mean age remained unchanged (2013 81.0 ± 6.1; 2020 80.8 ± 6.4; P = 0.976) with patients ≥ 80 years accounting for about two-third of the treated cohort. Periprocedural complications including bleeding (2013 24.5%; 2020 12.1%; P < 0.001), vascular complications (2013 20.7%; 2020 11.7%; P < 0.001) and new permanent pacemaker implantation (2013 20.1%; 2020 13.8%, P < 0.001) decreased significantly. Similarly, the 30-day mortality decreased from 5.4% to 2.1% (P < 0.001), but remained high in high-risk patients (STS > 8% 2013 7.5%; 2020 6.9%; P = 0.778).

conclusionFrom 2013 to 2020, mortality and burden of complications following TAVI procedure significantly decreased in a large multicenter registry from Germany. Proportion of elderly patients remained stable, while the surgical risk profile decreased.

Indexed as

Aortic Valve StenosisHeart Valve Prosthesis ImplantationTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic ValveGermanyHumansRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeAortic stenosisLow riskTAVI

Identifiers

PMID34751789
PMCPMC9334359
OpenAlexW3211508841

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.