Evidence map›Paper›PMID 34751628›Full record

Trial reportAnnals of medicine2021

Unattended compared to traditional blood pressure measurement in patients with rheumatoid arthritis: a randomised cross-over study.

Elena Bartoloni, Fabio Angeli, Elisa Marcucci, Carlo Perricone, Giacomo Cafaro, Clara Riccini, Lorenzo Spighi, Benedetta Gildoni, Claudio Cavallini, Paolo Verdecchia and 1 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Elena BartoloniRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Fabio AngeliDepartment of Medicine and Surgery, University of Insubria and Department of Medicine and Cardiopulmonary Rehabilitation, Maugeri Care and Research Institutes, IRCCS Tradate, Varese, Italy.ORCID 0000-0003-4925-7985
Elisa MarcucciRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Carlo PerriconeRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Giacomo CafaroRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Clara RicciniDepartment of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.
Lorenzo SpighiDepartment of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.
Benedetta GildoniRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Claudio CavalliniDepartment of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.
Paolo VerdecchiaDepartment of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.
Roberto GerliRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
University of Perugia · ITAzienda Ospedaliera di Perugia · ITUniversity of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is characterised by a high prevalence, low awareness and poor control among rheumatoid arthritis (RA) patients. Correct blood pressure (BP) measurement is highly important in these subjects. The "unattended" BP measurement aims to reduce the "white-coat effect," a phenomenon associated with cardiovascular risk. Data on "unattended" BP measurement in RA and its impact on hypertensive organ damage are very limited.

methodsBP was measured in the same patient both traditionally ("attended" BP) and by the "unattended" protocol (3 automated office BP measurements, at 1-min intervals, after 5 min of rest, with patient left alone) by a randomised cross-over design. Patients underwent clinical examination, 12-lead electrocardiography and trans-thoracic echocardiography to evaluate cardiac damage.

resultsSixty-two RA patients (mean age 67 ± 9 years, 87% women) were enrolled. Hypertension was diagnosed in 79% and 66% of patients according to ACC/AHA and ESC/ESH criteria, respectively. Concordance correlation coefficients between the two techniques were 0.55 (95%, CI 0.38-0.68) for systolic BP and 0.73 (95%, CI 0.60-0.82) for diastolic BP. "Unattended" (121.7/68.6 mmHg) was lower than "attended" BP (130.5/72.8 mmHg) for systolic and diastolic BP (both

conclusionsIn RA patients, "unattended" BP is lower than traditional ("attended") BP and more closely associated with LV mass. In these patients, the "unattended" automated BP measurement is a promising tool which requires further evaluation.KEY MESSAGES"Unattended" automated blood pressure registration, aimed to reduce the "white-coat effect" is lower than "attended" value in rheumatoid arthritis patients."Unattended" blood pressure is more closely associated with left ventricular mass than "attende" registration.

Indexed as

AgedAged, 80 and overAge FactorsArthritis, RheumatoidBlood PressureBlood Pressure DeterminationCardiovascular DiseasesCross-Over StudiesFemaleHumansHypertensionMaleMiddle AgedReproducibility of ResultsWhite Coat Hypertensionblood pressure measurementechocardiographyelectrocardiographyhypertensionleft ventricular hypertrophyRheumatoid arthritis

Identifiers

PMID34751628
PMCPMC8583925
OpenAlexW3214699098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.