Evidence map›Paper›PMID 34751489›Full record

ArticleCancer science2022

Circulating naïve and effector memory T cells correlate with prognosis in head and neck squamous cell carcinoma.

Hideyuki Takahashi, Koichi Sakakura, Shota Ida, Reika Kawabata-Iwakawa, Toshiyuki Matsuyama, Hiroe Tada, Ikko Mito, Kazuaki Chikamatsu

Abstract read
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hideyuki TakahashiDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.ORCID https://orcid.org/0000-0002-2465-3992
Koichi SakakuraDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Shota IdaDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Reika Kawabata-IwakawaDivision of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Maebashi, Japan.
Toshiyuki MatsuyamaDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hiroe TadaDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Ikko MitoDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kazuaki ChikamatsuDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.ORCID https://orcid.org/0000-0002-7739-0102

Funding

Ministry of Education, Culture, Sports, Science and Technology, Japan 20H03834Ministry of Education, Culture, Sports, Science and Technology, Japan 20K18243
6 · The paper itself

Abstract

T-cell memory is an important mechanism for long-term protection against diverse pathogens. Generation and persistence of memory T cells are vital components of anti-tumor immunity, given their ability to persist for prolonged durations, as well as activate and migrate rapidly. In the present study, we investigated the clinical and prognostic significance of T-cell subsets in the peripheral circulation of patients with head and neck squamous cell carcinoma (HNSCC). Moreover, we calculated the enrichment scores of T-cell subsets in primary tumor tissues and compared their clinical characteristics using a public database. Multivariate survival analyses of circulating T-cell parameters revealed that clinical parameters, except M factor, were not independent prognostic factors, whereas proportions of CD8

Indexed as

Biomarkers, TumorCD8-Positive T-LymphocytesGene Expression ProfilingGene Expression RegulationHead and Neck NeoplasmsHigh-Throughput Nucleotide SequencingHumansMemory T CellsNeoplasm StagingPapillomavirus InfectionsPrognosisSequence Analysis, RNASquamous Cell Carcinoma of Head and NeckBiomarkers, Tumorcancer immunologyhead and neck squamous cell carcinomaperipheral blood mononuclear cellT-cell memorytumor-infiltrating lymphocyte

Identifiers

PMID34751489
PMCPMC8748237

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.