Evidence map›Paper›PMID 34751296›Full record

ArticleFood & function2021

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models.

Aurélie de Rus Jacquet, Abeje Ambaw, Mitali Arun Tambe, Sin Ying Ma, Michael Timmers, Mary H Grace, Qing-Li Wu, James E Simon, George P McCabe, Mary Ann Lila and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Aurélie de Rus JacquetDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. jrochet@purdue.edu.ORCID http://orcid.org/0000-0002-5548-8045
Abeje AmbawDepartment of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Mitali Arun TambeDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. jrochet@purdue.edu.
Sin Ying MaDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. jrochet@purdue.edu.
Michael TimmersPlants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA.
Mary H GracePlants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA.
Qing-Li WuDepartment of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA.
James E SimonDepartment of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA.
George P McCabeDepartment of Statistics, Purdue University, West Lafayette, IN 47907, USA.
Mary Ann LilaPlants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA.ORCID http://orcid.org/0000-0002-4928-3836
Riyi ShiDepartment of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA.
Jean-Christophe RochetDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA. jrochet@purdue.edu.
Purdue University West Lafayette · USNorth Carolina State University · USRutgers, The State University of New Jersey · US

Funding

PROJECT 4 - POLYPHENOLS AND DAMAGE IN THE EYEP50AT000477 · NCCIH · PURDUE UNIVERSITY WEST LAFAYETTE · PI WEAVER, CONNIE MARIE · 2000 to 2010
$15.0M
Anthocyanins Derivatives for Drug Discovery in Aging Neurodegenerative DisordersR21AG039718 · NIA · PURDUE UNIVERSITY · PI COLBY, DAVID A · 2011 to 2012
$335k
Role of endosulfine-alpha expression and phosphorylation in Parkinson's DiseaseR03NS108229 · NINDS · PURDUE UNIVERSITY · PI ROCHET, JEAN-CHRISTOPHE · 2020 to 2021
$220k
Mechanisms of DJ-1 Protection against methamphetamine neurotoxicity.R03DA027111 · NIDA · PURDUE UNIVERSITY · PI ROCHET, JEAN-CHRISTOPHE · 2011 to 2012
$144k
NCCIH NIH HHS P50 AT000477NIA NIH HHS R21 AG039718NIDA NIH HHS R03 DA027111NINDS NIH HHS R03 NS108229
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by nigrostriatal degeneration and the spreading of aggregated forms of the presynaptic protein α-synuclein (aSyn) throughout the brain. PD patients are currently only treated with symptomatic therapies, and strategies to slow or stop the progressive neurodegeneration underlying the disease's motor and cognitive symptoms are greatly needed. The time between the first neurobiochemical alterations and the initial presentation of symptoms is thought to span several years, and early neuroprotective dietary interventions could delay the disease onset or slow PD progression. In this study, we characterized the neuroprotective effects of isoflavones, a class of dietary polyphenols found in soy products and in the medicinal plant red clover (

Indexed as

AnimalsAstrocytesCells, CulturedDietary SupplementsDopaminergic NeuronsFemaleGlycine maxHumansIsoflavonesMaleModels, BiologicalNeuroprotective AgentsParkinson DiseasePhytochemicalsRatsRats, Sprague-DawleyIsoflavonesNeuroprotective AgentsPhytochemicals

Identifiers

PMID34751296
PMCPMC10822195
OpenAlexW3186851586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.