Evidence map›Paper›PMID 34751268›Full record

ArticlebioRxiv : the preprint server for biology2021

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination.

Wooseob Kim, Julian Q Zhou, Alexandria J Sturtz, Stephen C Horvath, Aaron J Schmitz, Tingting Lei, Elizaveta Kalaidina, Mahima Thapa, Wafaa B Alsoussi, Alem Haile and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 22 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Wooseob KimDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Julian Q ZhouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Alexandria J SturtzDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Stephen C HorvathDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Aaron J SchmitzDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Tingting LeiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Elizaveta KalaidinaDivision of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Mahima ThapaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Wafaa B AlsoussiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Alem HaileClinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA.
Michael K KlebertClinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA.
Teresa SuessenMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Luis Parra-RodriguezDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Philip A MuddDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.
William D MiddletonMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Sharlene A TeefeyMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Iskra PusicDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jane A O'HalloranDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Rachel M PrestiDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jackson S TurnerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Ali H EllebedyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · USMallinckrodt (United States) · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCERT32CA009547 · NCI · WASHINGTON UNIVERSITY · PI ROBERT DAVID SCHREIBER · 1986 to 2026
$12.1M
DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9M
Programming Durable Immune Responses To VaccinationU01AI141990 · NIAID · WASHINGTON UNIVERSITY · PI Ali Hassan Ellebedy · 2019 to 2026
$5.3M
NCATS NIH HHS UL1 TR002345NCI NIH HHS T32 CA009547NIAID NIH HHS 75N93019C00051NIAID NIH HHS HHSN272201400006CNIAID NIH HHS HHSN272201400008CNIAID NIH HHS U01 AI141990NIAID NIH HHS U01 AI150747
6 · The paper itself

Abstract

Germinal centres (GC) are lymphoid structures where vaccine-responding B cells acquire affinity-enhancing somatic hypermutations (SHM), with surviving clones differentiating into memory B cells (MBCs) and long-lived bone marrow plasma cells (BMPCs)

Identifiers

PMID34751268
PMCPMC8575138
OpenAlexW3209108102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.