Evidence map›Paper›PMID 34751192›Full record

ArticleNature communications2021

Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22.

Alfred Fillol-Salom, Rodrigo Bacigalupe, Suzanne Humphrey, Yin Ning Chiang, John Chen, José R Penadés

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Exploring phage-host interactions inMicrobiology spectrum · 2025
    Article
  12. Article
  13. Article
  14. Genetics, ecology and evolution of phage satellites.Nature reviews. Microbiology · 2025
    Review
  15. Article
  16. Re-evaluating what makes a phage unsuitable for therapy.npj antimicrobials and resistance · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alfred Fillol-Salom *Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.ORCID http://orcid.org/0000-0002-6464-285X
Rodrigo Bacigalupe *Dep. Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113, Moncada, Spain.ORCID http://orcid.org/0000-0001-7310-997X
Suzanne HumphreyInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.ORCID http://orcid.org/0000-0002-9893-3209
Yin Ning ChiangDepartment of Microbiology and Immunology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9404-6023
John ChenDepartment of Microbiology and Immunology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore, Singapore. miccjy@nus.edu.sg.ORCID http://orcid.org/0000-0002-2318-1823
José R PenadésInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK. j.penades@imperial.ac.uk.ORCID http://orcid.org/0000-0002-6439-5262

Funding

Biotechnology and Biological Sciences Research Council BB/N002873/1Biotechnology and Biological Sciences Research Council BB/S003835/1Biotechnology and Biological Sciences Research Council BB/V002376/1Medical Research Council MR/L015080/1Medical Research Council MR/M003876/1Medical Research Council MR/S00940X/1Medical Research Council MR/S00940X/2Medical Research Council MR/T030062/1Medical Research Council MR/V000772/1Wellcome TrustWellcome Trust 201531/Z/16/Z
6 · The paper itself

Abstract

Lysogenic induction ends the stable association between a bacteriophage and its host, and the transition to the lytic cycle begins with early prophage excision followed by DNA replication and packaging (ERP). This temporal program is considered universal for P22-like temperate phages, though there is no direct evidence to support the timing and sequence of these events. Here we report that the long-standing ERP program is an observation of the experimentally favored Salmonella phage P22 tsc

Indexed as

Bacteriophage P22DNA ReplicationTransduction, Genetic

Identifiers

PMID34751192
PMCPMC8575938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.