ArticleJournal of Korean medical science2021
Association of Gastroesophageal Reflux Disease with Preterm Birth: Machine Learning Analysis.
Article in Journal of Korean medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Machine learning to predict adverse perinatal outcomes: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Association Between Gastroesophageal Reflux Disease and Periodontitis: A Longitudinal Follow-Up Study from the Korean National Health Screening Cohort.Biomedicines · 2024Article
- Accelerating adverse pregnancy outcomes research amidst rising medication use: parallel retrospective cohort analyses for signal prioritization.BMC medicine · 2024Article
- Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization.International journal of women's health · 2024Article
- Associations of Preterm Birth with Dental and Gastrointestinal Diseases: Machine Learning Analysis Using National Health Insurance Data.International journal of environmental research and public health · 2023Article
- Article
- Machine learning-based risk factor analysis of necrotizing enterocolitis in very low birth weight infants.Scientific reports · 2022Article
- Explainable Artificial Intelligence in the Early Diagnosis of Gastrointestinal Disease.Diagnostics (Basel, Switzerland) · 2022Review
- Machine learning-based risk factor analysis of adverse birth outcomes in very low birth weight infants.Scientific reports · 2022Article
- Machine Learning on Early Diagnosis of Depression.Psychiatry investigation · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study used machine learning and population data for testing the associations of preterm birth with gastroesophageal reflux disease (GERD) and periodontitis.
methodsRetrospective cohort data came from Korea National Health Insurance Service claims data for all women who aged 25-40 years and gave births for the first time as singleton pregnancy during 2015-2017 (405,586 women). The dependent variable was preterm birth during 2015-2017 and the independent variables were GERD (coded as no vs. yes) for each of the years 2002-2014, periodontitis (coded as no vs. yes) for each of the years 2002-2014, age (year) in 2014, socioeconomic status in 2014 measured by an insurance fee, and region (city) (coded as no vs. yes) in 2014. Random forest variable importance was adopted for finding main predictors of preterm birth and testing its associations with GERD and periodontitis.
resultsBased on random forest variable importance, main predictors of preterm birth during 2015-2017 were socioeconomic status in 2014, age in 2014, GERD for the years 2012, 2014, 2010, 2013, 2007 and 2009, region (city) in 2014 and GERD for the year 2006. The importance rankings of periodontitis were relatively low.
conclusionPreterm birth has a stronger association with GERD than with periodontitis. For the prevention of preterm birth, preventive measures for GERD would be essential together with the improvement of socioeconomic status for pregnant women. Especially, it would be vital to promote active counseling for general GERD symptoms (neglected by pregnant women).
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