Evidence map›Paper›PMID 34750769›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2022

Chronic Hypoxia Inhibits Respiratory Complex IV Activity and Disrupts Mitochondrial Dynamics in the Fetal Guinea Pig Forebrain.

Tabitha M Quebedeaux, Hong Song, Jamiu Giwa-Otusajo, Loren P Thompson

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tabitha M QuebedeauxDepartment of Obstetrics, Gynecology, & Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA.
Hong SongDepartment of Obstetrics, Gynecology, & Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA.
Jamiu Giwa-OtusajoDepartment of Obstetrics, Gynecology, & Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA.
Loren P ThompsonDepartment of Obstetrics, Gynecology, & Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA. lthompson1@umm.edu.ORCID 0000-0003-1693-3617
University of Maryland, Baltimore · US

Funding

Impact of Prenatal Hypoxia on Mitochondrial Function of Offspring HeartsR01HL126859 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, EUGENE D. · 2015 to 2022
$3.7M
NHLBI NIH HHS R01 HL126859
6 · The paper itself

Abstract

Mitochondrial dysfunction is an underlying cause of childhood neurological disease secondary to the crucial role of mitochondria in proper neurodevelopment. We hypothesized that chronic intrauterine hypoxia (HPX) induces mitochondrial deficits by altering mitochondrial biogenesis and dynamics in the fetal brain. Pregnant guinea pigs were exposed to either normoxia (NMX, 21%O

Indexed as

AnimalsElectron Transport Complex IElectron Transport Complex IVFemaleFetal HypoxiaGuinea PigsMitochondrial DynamicsPregnancyProsencephalonElectron Transport Complex IElectron Transport Complex IVBrainDynamicsFetalHypoxiaMitochondriaRespiratory complex

Identifiers

PMID34750769
OpenAlexW3213203602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.