ArticleSocial cognitive and affective neuroscience2022
Maternal dopamine encodes affective signals of human infants.
Article in Social cognitive and affective neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Social Physiology: Human homeostasis is more efficient in social proximity.Science advances · 2026Article
- Lactation increases food seeking and palatable feeding through mesolimbic dopamine signaling in mice.Cell reports · 2026Article
- Mesolimbic dopamine signaling mediates increased hedonic feeding and food seeking in lactating mice.bioRxiv : the preprint server for biology · 2026Article
- Psychedelic therapy and postpartum depression: priorities and prospects.Therapeutic advances in psychopharmacology · 2026Review
- Underexplored Connections Between Diabetes, Hypomanic States and Insecure Attachment.Psychology research and behavior management · 2025Review
- Stress-induced modulation of maternal behavior and mesolimbic dopamine function.Current opinion in behavioral sciences · 2024Article
- Review
- Breastfeeding at Any Cost? Adverse Effects of Breastfeeding Pain on Mother-Infant Behavior.Biology · 2023Article
- Evidence for cultural differences in affect during mother-infant interactions.Scientific reports · 2023Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Mothers are highly responsive to their offspring. In non-human mammals, mothers secrete dopamine in the nucleus accumbens (NAcc) in response to their pups. Yet, it is still unknown which aspect of the offspring behavior elicits dopaminergic responses in mothers. Here, we tested whether infants' affective signals elicit dopaminergic responses in the NAcc of human mothers. First, we conducted a behavioral analysis on videos of infants' free play and quantified the affective signals infants spontaneously communicated. Then, we presented the same videos to mothers during a magnetic resonance-positron emission tomography scan. We traced the binding of [11C]raclopride to free D2/3-type receptors to assess maternal dopaminergic responses during the infant videos. When mothers observed videos with many infant signals during the scan, they had less [11C]raclopride binding in the right NAcc. Less [11C]raclopride binding indicates that less D2/3 receptors were free, possibly due to increased endogenous dopamine responses to infants' affective signals. We conclude that NAcc D2/3 receptors are involved in maternal responsiveness to affective signals of human infants. D2/3 receptors have been associated with maternal responsiveness in nonhuman animals. This evidence supports a similar mechanism in humans and specifies infant-behaviors that activate the maternal dopaminergic system, with implications for social neuroscience, development and psychopathology.
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Registered trials
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