Evidence map›Paper›PMID 34750602›Full record

ReviewChemical communications (Cambridge, England)2021

Amphiphilic DNA nanostructures for bottom-up synthetic biology.

Roger Rubio-Sánchez, Giacomo Fabrini, Pietro Cicuta, Lorenzo Di Michele

Abstract readReview
In one paragraph

Review in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Internal Phase Separation in Synthetic DNA Condensates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Review
  8. DNA Origami Vesicle Sensors with Triggered Single-Molecule Cargo Transfer.Angewandte Chemie (International ed. in English) · 2024
    Article
  9. Enzyme-Responsive DNA Condensates.Journal of the American Chemical Society · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Reaction-Diffusion Patterning of DNA-Based Artificial Cells.Journal of the American Chemical Society · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roger Rubio-SánchezBiological and Soft Systems, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. l.di-michele@imperial.ac.uk.ORCID http://orcid.org/0000-0001-5574-5809
Giacomo FabriniDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.ORCID http://orcid.org/0000-0001-8601-1680
Pietro CicutaBiological and Soft Systems, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. l.di-michele@imperial.ac.uk.ORCID http://orcid.org/0000-0002-9193-8496
Lorenzo Di MicheleDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.ORCID http://orcid.org/0000-0002-1458-9747

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA nanotechnology enables the construction of sophisticated biomimetic nanomachines that are increasingly central to the growing efforts of creating complex cell-like entities from the bottom-up. DNA nanostructures have been proposed as both structural and functional elements of these artificial cells, and in many instances are decorated with hydrophobic moieties to enable interfacing with synthetic lipid bilayers or regulating bulk self-organisation. In this feature article we review recent efforts to design biomimetic membrane-anchored DNA nanostructures capable of imparting complex functionalities to cell-like objects, such as regulated adhesion, tissue formation, communication and transport. We then discuss the ability of hydrophobic modifications to enable the self-assembly of DNA-based nanostructured frameworks with prescribed morphology and functionality, and explore the relevance of these novel materials for artificial cell science and beyond. Finally, we comment on the yet mostly unexpressed potential of amphiphilic DNA-nanotechnology as a complete toolbox for bottom-up synthetic biology - a figurative and literal scaffold upon which the next generation of synthetic cells could be built.

Indexed as

Synthetic BiologyDNANanostructuresSurface-Active AgentsDNASurface-Active Agents

Identifiers

PMID34750602
PMCPMC8631003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.