Evidence map›Paper›PMID 34750551›Full record

ReviewNature reviews. Nephrology2022

Health inequities and the inappropriate use of race in nephrology.

Nwamaka D Eneanya, L Ebony Boulware, Jennifer Tsai, Marino A Bruce, Chandra L Ford, Christina Harris, Leo S Morales, Michael J Ryan, Peter P Reese, Roland J Thorpe and 5 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 3 pooled it
29.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Article
  7. A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  8. Restoring time lost to race-based medicine.Nature reviews. Urology · 2026
    Article
  9. Family History of Kidney Failure, APOL1 Risk Variants, Social Determinants of Health, and Risk of CKD Progression: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Observational
  10. Article
  11. Article
  12. Review
  13. Revamping the KRESCENT Core Curriculum: The KRESCENT 2.0 Program Report.Canadian journal of kidney health and disease · 2026
    Article
  14. A microsimulation-based framework for mitigating societal bias in primary care data.medRxiv : the preprint server for health sciences · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. How to Leverage Implementation Science to Achieve Equity in Nephrology Care Delivery.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Article
  19. Article
  20. Observational

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 3 countries.

Nwamaka D EneanyaRenal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Nwamaka.eneanya@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-0508-3410
L Ebony BoulwareDivision of General Internal Medicine, Duke University School of Medicine, Durham, NC, USA.
Jennifer TsaiDepartment of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.
Marino A BruceProgram for Research on Faith, Justice, and Health, Department of Behavioral and Social Sciences, University of Houston College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0643-1640
Chandra L FordCenter for the Study of Racism, Social Justice & Health, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Christina HarrisVA Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Leo S MoralesDivision of General Internal Medicine, University of Washington, Seattle, WA, USA.
Michael J RyanDivision of General Internal Medicine, University of Washington, Seattle, WA, USA.
Peter P ReeseRenal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Roland J ThorpeProgram for Research on Men's Health, Hopkins Center for Health Disparities Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michelle MorseDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Valencia WalkerDepartment of Paediatrics, Ohio State University College of Medicine, Columbus, OH, USA.
Fatiu A ArogundadeDepartment of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria.
Antonio A LopesClinical Epidemiology and Evidence-Based Medicine Unit of the Edgard Santos University Hospital and Department of Internal Medicine, Federal University of Bahia, Salvador, Brazil.
Keith C NorrisVA Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3071-0700
University of California, Los Angeles · USUniversity of Pennsylvania · USUniversity of Washington · USBrigham and Women's Hospital · USDuke University · USJohns Hopkins University · USObafemi Awolowo University · NGThe Ohio State University · USUniversidade Federal da Bahia · BRUniversity of Houston · USYale University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE A SARKISIAN · 2002 to 2026
$19.7M
Residential Segregation and Health Care Disparities P60MD000214 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI GASKIN, DARRELL J. · 2002 to 2016
$16.8M
Why Place MattersU54MD000214 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI THORPE, ROLAND J. · 2017 to 2022
$8.8M
The Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research - Research Ed ComponentP30AG059298 · NIA · JOHNS HOPKINS UNIVERSITY · PI Joseph John Gallo, ROLAND J. THORPE · 2018 to 2026
$7.1M
Obesity Health Disparities Research PRIDE Program (OHD PRIDE)R25HL126145 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI BEECH, BETTINA M., BRUCE, MARINO A · 2014 to 2025
$3.9M
Longevity and Stress in African American FamiliesR01AG054363 · NIA · WAYNE STATE UNIVERSITY · PI THORPE, ROLAND J., WHITFIELD, KEITH E. · 2016 to 2020
$3.4M
Stress and Mortality Among Black MenK02AG059140 · NIA · JOHNS HOPKINS UNIVERSITY · PI THORPE, ROLAND J. · 2018 to 2022
$1.1M
Integrating Conservative Kidney Management Options and Advance Care Planning Into a Pre-Dialysis Educational ProgramK23DK114526 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ENEANYA, NWAMAKA · 2017 to 2021
$819k
NCATS NIH HHS UL1 TR001881NHLBI NIH HHS R25 HL126145NIA NIH HHS K02 AG059140NIA NIH HHS P30 AG021684NIA NIH HHS P30 AG059298NIA NIH HHS R01 AG054363NIDDK NIH HHS K23 DK114526NIMHD NIH HHS P60 MD000214NIMHD NIH HHS U54 MD000214
6 · The paper itself

Abstract

Chronic kidney disease is an important clinical condition beset with racial and ethnic disparities that are associated with social inequities. Many medical schools and health centres across the USA have raised concerns about the use of race - a socio-political construct that mediates the effect of structural racism - as a fixed, measurable biological variable in the assessment of kidney disease. We discuss the role of race and racism in medicine and outline many of the concerns that have been raised by the medical and social justice communities regarding the use of race in estimated glomerular filtration rate equations, including its relationship with structural racism and racial inequities. Although race can be used to identify populations who experience racism and subsequent differential treatment, ignoring the biological and social heterogeneity within any racial group and inferring innate individual-level attributes is methodologically flawed. Therefore, although more accurate measures for estimating kidney function are under investigation, we support the use of biomarkers for determining estimated glomerular filtration rate without adjustments for race. Clinicians have a duty to recognize and elucidate the nuances of racism and its effects on health and disease. Otherwise, we risk perpetuating historical racist concepts in medicine that exacerbate health inequities and impact marginalized patient populations.

Indexed as

NephrologyRacismHealth InequitiesHealth Status DisparitiesHumansSocial JusticeUnited States

Identifiers

PMID34750551
PMCPMC8574929
OpenAlexW3213752583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.