ArticlePediatric research2022
Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Maternal Inflammation Likely Drives Impaired Immune Responses to Respiratory Syncytial Virus in HIV-Exposed Uninfected Infants.The Journal of infectious diseases · 2026Article
- Maternal COVID-19 infection associated with offspring neurodevelopmental disorders.Molecular psychiatry · 2025Article
- Maternal Immune Activation and Neurodevelopmental Disorders: Integrating Molecular, Cellular and Systems Mechanisms.Neuropsychiatric disease and treatment · 2025Review
- The fetal programming effect of maternal immune activation (MIA) on the offspring's immune system.Seminars in immunopathology · 2024Review
- Review
- Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment.Journal of neuroinflammation · 2024Article
- Impact of SARS-CoV-2 infection during pregnancy on the placenta and fetus.Seminars in perinatology · 2024Review
- Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants.Nature communications · 2024Article
- Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19.Pediatric research · 2024Article
- A review of single-cell transcriptomics and epigenomics studies in maternal and child health.Epigenomics · 2024Review
- Enhanced fetal hematopoiesis in response to symptomatic SARS-CoV-2 infection during pregnancy.Communications medicine · 2023Article
- Mild/asymptomatic COVID-19 in unvaccinated pregnant mothers impairs neonatal immune responses.JCI insight · 2023Article
- SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics.Med (New York, N.Y.) · 2023Article
- Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues.bioRxiv : the preprint server for biology · 2023Article
- COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy.Translational research : the journal of laboratory and clinical medicine · 2023Review
- Immune Responses to SARS-CoV-2 in Pregnancy: Implications for the Health of the Next Generation.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- COVID-19 in pregnancy: implications for fetal brain development.Trends in molecular medicine · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundDuring the COVID-19 pandemic, thousands of pregnant women have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The implications of maternal SARS-CoV-2 infection on fetal and childhood well-being need to be characterized. We aimed to characterize the fetal immune response to maternal SARS-CoV-2 infection.
methodsWe performed single-cell RNA-sequencing and T cell receptor sequencing on cord blood mononuclear cells (CBMCs) from newborns of mothers infected with SARS-CoV-2 in the third trimester (cases) or without SARS-CoV-2 infection (controls).
resultsWe identified widespread gene expression changes in CBMCs from cases, including upregulation of interferon-stimulated genes and major histocompatibility complex genes in CD14
conclusionsAs none of the infants were infected with SARS-CoV-2, our results suggest that maternal SARS-CoV-2 infection might modulate the fetal immune system in the absence of vertical transmission. IMPACT: The implications of maternal SARS-CoV-2 infection in the absence of vertical transmission on fetal and childhood well-being are poorly understood. Maternal SARS-CoV-2 infection might modulate the fetal immune system in the absence of vertical transmission. This study raises important questions about the untoward effects of maternal SARS-CoV-2 on the fetus, even in the absence of vertical transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.