Evidence map›Paper›PMID 34750484›Full record

Trial reportScientific reports2021

Renal and hepatic function of patients with severe tricuspid regurgitation undergoing inferior caval valve implantation.

Bernd Hewing, Isabel Mattig, Fabian Knebel, Verena Stangl, Michael Laule, Karl Stangl, Henryk Dreger

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Bernd Hewing *Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Isabel Mattig *Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Fabian KnebelCorporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Verena StanglCorporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Michael LauleCorporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Karl StanglCorporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Henryk DregerCorporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Medizinische Klinik Mit Schwerpunkt Kardiologie und Angiologie, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany. henryk.dreger@charite.de.
Freie Universität Berlin · DECharité - Universitätsmedizin Berlin · DEGerman Centre for Cardiovascular Research · DEHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to progressive abdominal-venous congestion severe tricuspid regurgitation (TR) is a common cause of cardiorenal and cardiohepatic syndrome. We initiated the TRICAVAL study to compare interventional valve implantation into the inferior vena cava (CAVI) versus optimal medical therapy (OMT) in severe TR. In the present subanalysis, we aimed to evaluate the effects of CAVI on clinical signs of congestion, renal and hepatic function. TRICAVAL was an investigator-initiated, randomized trial. Twenty-eight patients with severe TR were randomized to OMT or CAVI using an Edwards Sapien XT valve. Probands who completed the 3-month follow-up (CAVI [n = 8], OMT [n = 10]) were evaluated by medical history, clinical examination, and laboratory testing at baseline, 3 and 12 months. After 3 months, the CAVI group exhibited a significant reduction of body weight (from 80.7 [69.0-87.7] kg to 75.5 [63.8-84.6] kg, p < 0.05) and abdominal circumference (from 101.5 ± 13.8 cm to 96.3 ± 15.4 cm, p ≤ 0.01) and a trend to lower doses of diuretics compared to OMT. Renal and hepatic function parameters did not change significantly. Within a short-term follow-up, CAVI led to an improvement of clinical signs of venous congestion and a non-significant reduction of diuretic doses compared to OMT.

Indexed as

Blood Vessel Prosthesis ImplantationAcute DiseaseAgedAged, 80 and overFemaleHemodynamicsHumansKidneyLiverMaleTricuspid Valve InsufficiencyVena Cava, Inferior

Identifiers

PMID34750484
PMCPMC8576027
OpenAlexW3213890060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.