ArticleScientific reports2021
Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
42 citing papers in PubMed, 131 citations in OpenAlex.
- A mechanically robust and moisture-retentive hydrocolloid dressing for chronic wound management.Scientific reports · 2026Article
- Sodium Ascorbate-Accelerated Gelling Hydrogels With Rapid Self-Mineralized Capacity for Chronic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Development, Characterization, and In Vitro Hemostatic Assessment of an Alginate-Based Wound Dressing Incorporating Liposomal Curcumin.Gels (Basel, Switzerland) · 2026Article
- Ultra-High-Throughput Discovery of Multifunctional Polyphenolic Coatings on Droplet Microarrays.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Cellulose-Based Hydrogels for Chronic Wound Healing: Bridging Biomaterial Design and Clinical Unmet Needs.Gels (Basel, Switzerland) · 2026Review
- Synthesis and characterization of electroactive chitosan/gelatin/PEDOT:PSS hydrogels with mixed ionic-electronic conductivity for potential wound healing applications.RSC advances · 2026Article
- Anticancer activity of curcumin loaded hybrid system of silver-amine functionalized silica nanoparticles.Scientific reports · 2026Article
- Biopolymer Hydrogel-Based Nanocomposites Functionalized with Natural Products for Wound Dressings: Translational Advances in Drug Design, Development, and Therapeutic Wound Care.Drug design, development and therapy · 2026Review
- Transfersomal delivery ofDrug delivery · 2025Article
- Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing.Polymers · 2025Review
- Recent Advances of Silver Nanoparticles in Wound Healing: Evaluation of In Vivo and In Vitro Studies.International journal of molecular sciences · 2025Review
- Curcumin-Functionalized Ag and ZnO Nanoparticles: A Nanotherapeutic Approach for Treating Infections in Diabetic Wounds.Bioengineering (Basel, Switzerland) · 2025Article
- Injectable nanocomposite hydrogels for targeted intervention in cancer, wound healing, and bone and myocardial tissue engineering.Drug delivery and translational research · 2025Review
- Antioxidant, In Vitro Cytotoxicity, and Anti-diabetic Attributes of a Drug-Free Guar Gum Nanoformulation as a Novel Candidate for Diabetic Wound Healing.Molecular biotechnology · 2025Article
- Newly designed curcumin-loaded hybrid nanoparticles: a multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue regeneration.BMC biotechnology · 2025Article
- Wound treatment with curcumin prevents hypertrophic scarring and promotes remodeling by inhibiting fibroblast activation and regulating collagen deposition.Archives of dermatological research · 2025Article
- Application of Gelatin/Vanillin/FeACS omega · 2025Article
- Review
- Superior In Vivo Wound-Healing Activity of Biosynthesized Silver Nanoparticles with Nepeta cataria (Catnip) on Excision Wound Model in Rat.Biological trace element research · 2025Article
- Cannabidiol-Loaded Lipid Nanoparticles Incorporated in Polyvinyl Alcohol and Sodium Alginate Hydrogel Scaffold for Enhancing Cell Migration and Accelerating Wound Healing.Gels (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite promotes wound healing in in vivo studies on rats, accelerating wound closure by > 40% and reducing bacterial counts by 60% compared to commercial antibacterial gels. Histopathology indicates that the hydrogel composite enhances transition from the inflammation to proliferation stage of healing, promoting the formation of fibroblasts and new blood vessels, while target gene expression studies confirm that the accelerated tissue remodeling occurs along the normal pathways. As such these hydrogel composites show great promise as wound dressing materials with high antibacterial capacity.
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