ArticleScientific reports2021
Digital variance angiography allows about 70% decrease of DSA-related radiation exposure in lower limb X-ray angiography.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Digital variance angiography enables up to 80% reduction in stationary acquisition radiation dose during prostatic artery embolization: a prospective randomized trial.European radiology · 2026Trial
- Cone-Beam Computed Tomography Angiography Protocol Optimization in Peripheral and Visceral Interventions.Cardiovascular and interventional radiology · 2026Review
- Possible use of digital variance angiography in uterine fibroid embolization: a retrospective observational study.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Observational
- Deep learning-based frame synthesis enables radiation dose reduction in digital subtraction angiography imaging: a multicenter study.Frontiers in medicine · 2026Article
- Comparison of the performance of digital variance angiography and digital subtraction angiography in children with arteriovenous malformations: a retrospective observational study.European radiology experimental · 2025Observational
- Radiation exposure reduction in peripheral interventions using digital variance angiography versus conventional angiography.Scientific reports · 2025Article
- Clinical comparison of transfemoral vs. distal transradial access for lower extremity arteriography.Frontiers in surgery · 2025Review
- Quantitative Comparison of Color-Coded Parametric Imaging Technologies Based on Digital Subtraction and Digital Variance Angiography: A Retrospective Observational Study.Journal of imaging · 2024Article
- Digital variance angiography in patients undergoing lower limb arterial recanalization: cost-effectiveness analysis within the English healthcare setting.Journal of comparative effectiveness research · 2024Article
- The impact of increasing saline flush volume to reduce the amount of residual air in the delivery system of aortic prostheses-a randomized controlled trial.Frontiers in cardiovascular medicine · 2024Article
- Possible use of Digital Variance Angiography in Liver Transarterial Chemoembolization: A Retrospective Observational Study.Cardiovascular and interventional radiology · 2023Observational
- Radiation Exposure Reduction by Digital Variance Angiography in Lower Limb Angiography: A Randomized Controlled Trial.Journal of cardiovascular development and disease · 2023Article
- A State-of-the-Art Review of Intra-Operative Imaging Modalities Used to Quality Assure Endovascular Aneurysm Repair.Journal of clinical medicine · 2023Review
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
Our aim was to investigate whether the previously observed higher contrast-to-noise ratio (CNR) and better image quality of Digital Variance Angiography (DVA) - compared to Digital Subtraction Angiography (DSA) - can be used to reduce radiation exposure in lower limb X-ray angiography. This prospective study enrolled 30 peripheral artery disease patients (mean ± SD age 70 ± 8 years) undergoing diagnostic angiography. In all patients, both normal (1.2 µGy/frame; 100%) and low-dose (0.36 µGy/frame; 30%) protocols were used for the acquisition of images in three anatomical regions (abdominal, femoral, crural). The CNR of DSA and DVA images were calculated, and the visual quality was evaluated by seven specialists using a 5-grade Likert scale. For investigating non-inferiority, the difference of low-dose DVA and normal dose DSA scores (DVA30-DSA100) was analyzed. DVA produced two- to three-fold CNR and significantly higher visual score than DSA. DVA30 proved to be superior to DSA100 in the crural region (difference 0.25 ± 0.07, p < 0.001), and there was no significant difference in the femoral (- 0.08 ± 0.06, p = 0.435) and abdominal (- 0.10 ± 0.09, p = 0.350) regions. Our data show that DVA allows about 70% reduction of DSA-related radiation exposure in lower limb X-ray angiography, providing a potential new radiation protection tool for the patients and the medical staff.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.