Evidence map›Paper›PMID 34750414›Full record

ArticleScientific reports2021

Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing.

Jie Zheng, Yuan-Yuan Wu, Wen-Liang Fang, Xin-Ying Cai, Zeng-Yun-Ou Zhang, Chong-Xian Yu, Xiao-Dong Zheng, Feng-Li Xiao

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Special Issue "Molecular and Cellular Advances in Atopic Diseases".International journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jie Zheng *Department of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China.
Yuan-Yuan Wu *Department of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China.
Wen-Liang FangClinical College, Anhui Medical University, Hefei, Anhui, China.
Xin-Ying CaiDepartment of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China.
Zeng-Yun-Ou ZhangDepartment of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China.
Chong-Xian YuDepartment of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China.
Xiao-Dong ZhengDepartment of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China. zhengxiaodong.1234@163.com.
Feng-Li XiaoDepartment of Dermatology of First Affiliated Hospital, and Institute of Dermatology, Anhui Medical University, Science and Teaching Building, 81 Meishan Road, Hefei City, 230032, Anhui Province, China. xiaofengli@126.com.
Anhui Medical University · CN

Funding

National Natural Science Foundation of China No. 81172838Natural Science Foundation of Anhui Province No. 1708085MH217Scientific research activities of academic and technological leaders of Anhui Province No. 2017D141the Key Project of Natural Science Research in Colleges and Universities in Anhui Province No. KJ2016A367
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a common and complex skin disorder, and the 5q22.1 region had been reported to be associated with AD. To confirm the susceptibility gene for AD in the 5q22.1 region by haplotype and targeted capture sequencing. The haplotypes were reconstructed with the genotyping data of four SNPs and six deletions from 3624 Chinese Hans AD patients and 5076 controls. The targeted capture sequencing spanning 5q22.1 region was performed in the selected samples. The gene level enrichment analysis was done using loss of function variants. A total of 62 haplotypes were found, and the H15 haplotype had the strongest association with AD (P = 3.92 × 10

Indexed as

AdolescentAdultAsian PeopleCase-Control StudiesChildChild, PreschoolChinaChromosomes, Human, Pair 5Dermatitis, AtopicFemaleGenetic Predisposition to DiseaseHaplotypesHigh-Throughput Nucleotide SequencingHumansInfantInfant, NewbornMembrane ProteinsTMEM232 protein, human

Identifiers

PMID34750414
PMCPMC8576034
OpenAlexW3211707893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.