ArticleScientific reports2021
Association between family history and lung cancer risk among Chinese women in Singapore.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Etiology and risk factors for lung cancer in female Asian never smokers: a systematic review.Therapeutic advances in medical oncology · 2026Review
- Analysis and prediction of the burden of lung cancer attributable to diet low in fruits in China and the global from 1990 to 2021.PloS one · 2026Article
- Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium.International journal of cancer · 2025Article
- An early lung cancer diagnosis model for non-smokers incorporating ct imaging analysis and circulating genetically abnormal cells (CACs).BMC cancer · 2025Article
- The Association between Family History of Lung Cancer and Development of Lung Cancer: Analysis from the KoGES Data in Korea.Cancers · 2024Article
- Illuminating Shared Genetic Associations Between Oesophageal Carcinoma and Pulmonary Carcinoma Risk.Journal of Cancer · 2024Article
- Association between a family history of cancer and multiple primary lung cancer risks: a population-based analysis from China.BMC pulmonary medicine · 2023Article
- Genomic medicine and cancer clinical trial in Thailand.Cancer biology & medicine · 2023Article
- Lung cancer risk and exposure to air pollution: a multicenter North China case-control study involving 14604 subjects.BMC pulmonary medicine · 2023Article
- Gender disparities in incidence and projections of lung cancer in China and the United States from 1978 to 2032: an age-period-cohort analysis.Cancer causes & control : CCC · 2022Article
- Dietary factors and the risk of lung cancer by epidermal growth factor receptor mutation status and histological subtypes.Frontiers in public health · 2022Article
- Are calcium channel blockers related to lung cancer?Drug target insightsArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Risk factors of lung cancer unrelated to smoking are not well-studied, especially among women. Family history has been shown to play a role in predisposing individuals to lung cancer, but this relationship has not been investigated in the Southeast Asian population. A total of 1159 women were recruited in a case-control study conducted in public hospitals in Singapore from 2005 to 2008. After excluding participants with incomplete family history information, 374 cases and 785 controls remained in the final analysis. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression, adjusting for potential confounders. Overall, family history of lung cancer was associated with a higher risk for lung cancer (aOR 2.08, 95% CI 1.25-3.47). When stratified by smoking status, a significant association was observed among never-smokers (aOR 2.78, 95% CI 1.57-4.90). Further stratification by fruit consumption identified a significant association between family history of lung cancer and higher risk of lung cancer among never-smokers who had low fruit consumption (aOR 3.09, 95% CI 1.37-7.01). Our findings suggest that family history of lung cancer is a significant risk factor for lung cancer in Singaporean Chinese women, especially among never-smokers.
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