Evidence map›Paper›PMID 34750295›Full record

ArticleAIDS (London, England)2022

Association of HIV infection with outcomes among adults hospitalized with COVID-19.

Matthew S Durstenfeld, Kaiwen Sun, Yifei Ma, Fatima Rodriguez, Eric A Secemsky, Rushi V Parikh, Priscilla Y Hsue

Open access · greenAbstract read
In one paragraph

Article in AIDS (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Matthew S DurstenfeldDepartment of Medicine, University of California, San Francisco.
Kaiwen SunDepartment of Medicine, University of California, San Francisco.
Yifei MaDepartment of Medicine, University of California, San Francisco.
Fatima RodriguezDivision of Cardiovascular Medicine & Cardiovascular Institute, Stanford University, Stanford, California.
Eric A SecemskySmith Center for Outcomes Research in Cardiology, Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center.
Rushi V ParikhDivision of Cardiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA.
Priscilla Y HsueDepartment of Medicine, University of California, San Francisco.
University of California, San Francisco · USHarvard University · USSan Francisco General Hospital · USStanford University · USUniversity of California, Los Angeles · US

Funding

MOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4M
Impact of Treating Asymptomatic CMV Replication on Cardiovascular Risk in Treated HIV InfectionR01HL152957 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETER W HUNT, Priscilla Y. Hsue · 2020 to 2026
$3.7M
Role of Hematopoietic System and Proteomics in HIV-Associated CardiovascularDiseaseK24AI112393 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y. · 2014 to 2024
$1.9M
UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
SURPASS: (Statin Use and Risk Prediction of Atherosclerotic Cardiovascular Disease in minority Subgroups)K01HL144607 · NHLBI · STANFORD UNIVERSITY · PI RODRIGUEZ, FATIMA · 2019 to 2023
$856k
Shared Decision-Making to Improve the Health Status of Patients with Claudication: Developing and Implementing Strategies to Individualize Treatment DecisionsK23HL150290 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SECEMSKY, ERIC ALEXANDER · 2020 to 2024
$851k
American Heart Association-American Stroke Association 18CDA34110335NHLBI NIH HHS K01 HL144607NHLBI NIH HHS K12 HL143961NHLBI NIH HHS K23 HL150290NHLBI NIH HHS L30 HL159695NHLBI NIH HHS R01 HL152957NHLBI NIH HHS T32 HL007731NIAID NIH HHS K24 AI112393
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the association of HIV infection with outcomes among people hospitalized with COVID-19.

designA prospectively planned analysis of the American Heart Association's COVID-19 Cardiovascular Disease Registry.

settingOne hundred and seven academic and community hospitals in the United States from March through December 2020.

participantsConsecutive sample of 21 528 adults hospitalized with COVID-19 at participating hospitals. MAIN OUTCOME AND MEASURE: Primary outcome was predefined as in-hospital mortality. We used hierarchical mixed effects models to assess the association of HIV with in-hospital mortality accounting for patient demographics, comorbidities, and clustering by hospital. Secondary outcomes included major adverse cardiac events (MACE), severity of illness, and length of stay (LOS).

resultsThe registry included 220 people with HIV (PWH). PWH were younger and more likely to be male, Non-Hispanic Black, on Medicaid, and active tobacco users. Of the study population, 36 PWH (16.4%) died compared with 3290 (15.4%) without HIV [risk ratio 1.06; 95% confidence interval (95% CI) 0.79-1.43; P = 0.71]. After adjustment for age, sex, race, and insurance, HIV was not associated with in-hospital mortality (aOR 1.12; 95% CI 0.76-1.64; P = 0.58) with no change in effect after adding BMI and comorbidities (aOR 1.14; 95% CI 0.78-1.68; P = 0.51). HIV was not associated with MACE (aOR 0.99; 95% CI 0.69-1.44, P = 0.91), COVID severity (aOR 0.96; 95% CI 0.62-1.50; P = 0.86), or LOS (aOR 1.03; 95% CI 0.76-1.66; P = 0.21).

conclusionIn the largest study of PWH hospitalized with COVID-19 in the United States to date, we did not find significant associations between HIV and adverse outcomes including in-hospital mortality, MACE, or severity of illness.

Indexed as

COVID-19HIV InfectionsAdultFemaleHospitalizationHospital MortalityHumansMaleSARS-CoV-2United States

Identifiers

PMID34750295
PMCPMC8795492
OpenAlexW3212163640

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.