Evidence map›Paper›PMID 34750263›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca

Nicholas C Vierra, Samantha C O'Dwyer, Collin Matsumoto, L Fernando Santana, James S Trimmer

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. CaThe Journal of physiology · 2026
    Article
  4. CaClinical and experimental pharmacology & physiology · 2026
    Article
  5. Article
  6. Nanoscale CabioRxiv : the preprint server for biology · 2026
    Article
  7. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  8. Article
  9. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  10. Article
  11. Reduced Gene Dosage of the Psychiatric Risk GeneInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  14. Synapse-to-Nucleus ERK→CREB Transcriptional Signaling Requires Dendrite-to-Soma CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Review
  16. Glucocorticoids Rapidly Modulate CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicholas C VierraDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616.ORCID 0000-0001-7269-5399
Samantha C O'DwyerDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616.
Collin MatsumotoDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616.
L Fernando SantanaDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616.ORCID 0000-0002-4297-8029
James S TrimmerDepartment of Physiology and Membrane Biology, University of California Davis School of Medicine, Davis, CA 95616 jtrimmer@ucdavis.edu.ORCID 0000-0002-6117-3912
University of California, Davis · US

Funding

Multi-Scale Modeling of Vascular Signaling UnitsR01HL152681 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2020 to 2023
$2.4M
Neuronal Kv2.1 Potassium Channels as Organizers of Somatic L-Type Calcium Channel MicrodomainsR01NS114210 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES, SANTANA, LUIS F · 2020 to 2024
$2.3M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Tuning L-Type Ca Channel Activity in Arterial Smooth Muscle by Kv Channel-Mediated ClusteringR01HL144071 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANTANA, LUIS F, TRIMMER, JAMES S · 2018 to 2021
$2.0M
Dynamic modulation of ionic and lipid signaling by neuronal Kv2 channelsF32NS108519 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VIERRA, NICHOLAS CATIN · 2018 to 2020
$168k
NHLBI NIH HHS R01 HL144071NHLBI NIH HHS R01 HL152681NIGMS NIH HHS T32 GM099608NINDS NIH HHS F32 NS108519NINDS NIH HHS R01 NS114210
6 · The paper itself

Abstract

In mammalian brain neurons, membrane depolarization leads to voltage-gated Ca

Indexed as

AnimalsCalcium Channels, L-TypeCell MembraneCells, CulturedDendritesEndoplasmic ReticulumFemaleHEK293 CellsHippocampusHumansMaleMiceNeuronsPhosphorylationRatsShab Potassium ChannelsCalcium Channels, L-TypeShab Potassium Channelscalcium signalingexcitation–transcription couplingmembrane contact sitesvoltage-gated calcium channelsvoltage-gated potassium channels

Identifiers

PMID34750263
PMCPMC8609631
OpenAlexW3214152748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.