ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- Dynamic changes in amygdala and insula responses to the onset and offset of conditioned stimuli during threat learning.Scientific reports · 2026Article
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
- Endogenous opioid system modulates proximal and distal threat signals in the human brain.Molecular psychiatry · 2026Article
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- Affect Labeling During Pictorial Encoding Enhances Their Recognition and Reduces Amygdalar Responses to Negative Pictures.Brain and behavior · 2026Article
- Neural correlates of human fear conditioning and sources of variability in 2199 individuals.Nature communications · 2025Article
- The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse.bioRxiv : the preprint server for biology · 2025Article
- Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025Review
- Current State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Time-dependent neural arbitration between cue associative and episodic fear memories.Nature communications · 2024Article
- Article
- Neuroticism/Negative Emotionality Is Associated with Increased Reactivity to Uncertain Threat in the Bed Nucleus of the Stria Terminalis, Not the Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuroticism/negative emotionality is associated with increased reactivity to uncertain threat in the bed nucleus of the stria terminalis, not the amygdala.bioRxiv : the preprint server for biology · 2024Article
- Threat Memory in the Sensory Cortex: Insights from Olfaction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.Communications biology · 2024Article
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Distributed neural representations of conditioned threat in the human brain.Nature communications · 2024Article
- Dynamic threat-reward neural processing under semi-naturalistic ecologically relevant scenarios.Human brain mapping · 2024Article
- Acute Angiotensin II Receptor Blockade Facilitates Parahippocampal Processing During Memory Encoding in High-Trait-Anxious Individuals.Biological psychiatry global open science · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most of our knowledge about human emotional memory comes from animal research. Based on this work, the amygdala is often labeled the brain's "fear center", but it is unclear to what degree neural circuitries underlying fear and extinction learning are conserved across species. Neuroimaging studies in humans yield conflicting findings, with many studies failing to show amygdala activation in response to learned threat. Such null findings are often treated as resulting from MRI-specific problems related to measuring deep brain structures. Here we test this assumption in a mega-analysis of three studies on fear acquisition (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.