Evidence map›Paper›PMID 34750173›Full record

ArticleCold Spring Harbor perspectives in biology2021

Genetic and Cellular Contributions to Liver Regeneration.

Roger Liang, Yu-Hsuan Lin, Hao Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor perspectives in biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Hallmarks of regeneration.Cell stem cell · 2024
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roger Liang *Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Yu-Hsuan Lin *Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Hao ZhuChildren's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Funding

Improving hepatocellular carcinoma mouse modeling by understanding the malignant potential and biology of liver cell subpopulationsR01CA251928 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2020 to 2024
$2.7M
Investigating imitation SWI chromatin remodeling complexes in mammalian tissue regenerationR01DK125396 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2020 to 2023
$1.5M
NCI NIH HHS R01 CA251928NIDDK NIH HHS R01 DK125396
6 · The paper itself

Abstract

The regenerative capabilities of the liver represent a paradigm for understanding tissue repair in solid organs. Regeneration after partial hepatectomy in rodent models is well understood, while regeneration in the context of clinically relevant chronic injuries is less studied. Given the growing incidence of fatty liver disease, cirrhosis, and liver cancer, interest in liver regeneration is increasing. Here, we will review the principles, genetics, and cell biology underlying liver regeneration, as well as new approaches being used to study heterogeneity in liver tissue maintenance and repair.

Identifiers

PMID34750173
PMCPMC9438780

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.