ReviewEuropean respiratory review : an official journal of the European Respiratory Society2021
Development and clinical translation of tubular constructs for tracheal tissue engineering: a review.
Review in European respiratory review : an official journal of the European Respiratory Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Reinforcement of skin flap tracheal reconstruction with porous titanium nickelide implants: A novel approach to persistent tracheal defect closure.JTCVS techniques · 2026Article
- Development of a 3D-printed synthetic tracheal scaffold for partial tracheal wall reconstruction: an experimental animal study.BMC biomedical engineering · 2026Article
- [Application of Kartogenin in cartilage tissue engineering].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- [Application and challenges of tissue engineered scaffolds in treatment of long-segment laryngotracheal stenosis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.Frontiers in cell and developmental biology · 2026Review
- Current status, trend and progress of stem cells in tracheal tissue engineering research: an overview and perspectives.Stem cell research & therapy · 2025Review
- Method for Targeted Cellular Seeding of Tubular Tissue-Engineered Scaffolds for Tracheal Regeneration Approaches.ACS biomaterials science & engineering · 2025Article
- Engineered Anti-Senescence Trachea With Post-Transplanted Regenerative Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A case of tracheobronchomegaly misdiagnosed as COPD: case report and literature review.BMC pulmonary medicine · 2025Review
- Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering.Stem cell research & therapy · 2025Article
- Bioengineered tracheal graft with enhanced vascularization and mechanical stability for functional airway reconstruction.Regenerative therapy · 2025Review
- Ferrostatin-1 inhibits tracheal basal cell ferroptosis to facilitate the rapid epithelization of 3D-printed tissue-engineered tracheas.Stem cell research & therapy · 2025Article
- The role of the glutathione pathway in tracheal regeneration with aortic allografts through antioxidant-driven tissue integration.Communications biology · 2025Article
- Tissue-engineered tracheal implants: Advancements, challenges, and clinical considerations.Bioengineering & translational medicine · 2024Review
- Recent Advances in the Application of 3D-Printing Bioinks Based on Decellularized Extracellular Matrix in Tissue Engineering.ACS omega · 2024Review
- Preparation of Decellularized Tissue as Dual Cell Carrier Systems: A Step Towards Facilitating Re-epithelization and Cell Encapsulation for Tracheal Reconstruction.Annals of biomedical engineering · 2024Article
- Temporal control in shell-core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis.Regenerative biomaterials · 2024Article
- Tracheal replacement with aortic grafts: Bench to clinical practice.Regenerative therapy · 2023Review
- Construction of a novel cell-free tracheal scaffold promoting vascularization for repairing tracheal defects.Materials today. Bio · 2023Article
- Application of tissue engineering techniques in tracheal repair: a bibliometric study.Bioengineered · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective restoration of extensive tracheal damage arising from cancer, stenosis, infection or congenital abnormalities remains an unmet clinical need in respiratory medicine. The trachea is a 10-11 cm long fibrocartilaginous tube of the lower respiratory tract, with 16-20 tracheal cartilages anterolaterally and a dynamic trachealis muscle posteriorly. Tracheal resection is commonly offered to patients suffering from short-length tracheal defects, but replacement is required when the trauma exceeds 50% of total length of the trachea in adults and 30% in children. Recently, tissue engineering (TE) has shown promise to fabricate biocompatible tissue-engineered tracheal implants for tracheal replacement and regeneration. However, its widespread use is hampered by inadequate re-epithelialisation, poor mechanical properties, insufficient revascularisation and unsatisfactory durability, leading to little success in the clinical use of tissue-engineered tracheal implants to date. Here, we describe in detail the historical attempts and the lessons learned for tracheal TE approaches by contextualising the clinical needs and essential requirements for a functional tracheal graft. TE manufacturing approaches explored to date and the clinical translation of both TE and non-TE strategies for tracheal regeneration are summarised to fully understand the big picture of tracheal TE and its impact on clinical treatment of extensive tracheal defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.