Evidence map›Paper›PMID 34750114›Full record

ArticleEuropean respiratory review : an official journal of the European Respiratory Society2021

Sex and gender in respiratory physiology.

Antonella LoMauro, Andrea Aliverti

Open access · diamondAbstract read
In one paragraph

Article in European respiratory review : an official journal of the European Respiratory Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
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  6. Spirometric Lung Function Among Smokers and Non-Smokers: A Cross-Sectional Study in University Students.International journal of environmental research and public health · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
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  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Age Trajectories of OBiomolecules · 2025
    Article
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Antonella LoMauroDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy antonella.lomauro@polimi.it.ORCID https://orcid.org/0000-0002-1408-6971
Andrea AlivertiDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.ORCID https://orcid.org/0000-0002-2950-0231
Politecnico di Milano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex is a biological concept determined at conception. Gender is a social concept. Medicine recognises sex as a biological variable and recommends including sex as a factor in clinical practice norms and as a topic of bench and clinical research. Sex plays a role in respiratory physiology according to two pathways: hormones and anatomy, with females characterised by smaller dimensions at every level of the respiratory system. Sex hormones also play specific roles in lung inflammatory processes, breathing control and in response to diseases. The literature is extremely controversial because many factors need to be considered to avoid erroneous comparisons. The main difficulty lies in creating homogeneous groups of subjects according to age, body weight, lung/airway size, fluctuations in circulating hormone levels, and exercise protocol. Because almost all of the knowledge available in physiology is based on research in males, medicine for women is therefore less evidence-based than that being applied to men. Finally, the number of transsexual people is increasing and they represent new challenges for clinicians, due to the anatomical and physiological changes that they undergo.

Indexed as

ExerciseRespirationFemaleHumansLungMaleSex Factors

Identifiers

PMID34750114
PMCPMC9488190
OpenAlexW3212555953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.