SynthesisAnnals of the rheumatic diseases2022
Perceptions and experiences of individuals at-risk of rheumatoid arthritis (RA) knowing about their risk of developing RA and being offered preventive treatment: systematic review and thematic synthesis of qualitative studies.
Synthesis in Annals of the rheumatic diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Towards primary prevention of multiple sclerosis.Nature reviews. Neurology · 2026Review
- Dynamic psychological vulnerability and adaptation in rheumatoid arthritis: Trajectories, predictors, and interventions.World journal of psychiatry · 2026Review
- Living with palindromic rheumatism: a qualitative interview study.Rheumatology advances in practice · 2026Article
- Identifying people at risk of rheumatoid arthritis in primary care: a qualitative study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Prevention of Rheumatoid Arthritis in At-Risk Individuals: Current Status and Future Prospects.Drugs · 2024Review
- 'What is my risk really?': a qualitative exploration of preventive interventions among individuals at risk of rheumatoid arthritis.Rheumatology advances in practice · 2024Article
- Article
- Opportunities and challenges in early diagnosis of rheumatoid arthritis in general practice.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Preferences for preventive treatments for rheumatoid arthritis: discrete choice survey in the UK, Germany and Romania.Rheumatology (Oxford, England) · 2023Article
- Article
- Preferences and Insights for Participation in a Rheumatoid Arthritis Clinical Prevention Trial: A Mixed-Methods Study.ACR open rheumatology · 2022Article
- Perspectives of at-Risk Individuals on Preventive Intervention for Rheumatoid Arthritis: A Mini Review.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere is increasing interest in identifying individuals at-risk of rheumatoid arthritis (RA) and initiating early treatment to prevent or delay the onset of arthritis. We aimed to describe the perceptions and experiences of at-risk individuals and to inform the conduct of clinical trials and studies, and clinical practice.
methodsA systematic review and thematic synthesis of qualitative studies was conducted. Two review authors independently screened studies for inclusion, appraised their methodological quality using the Critical Appraisal Skills Programme checklist and assessed confidence in the findings using the Grading of Recommendations Assessment, Development and Evaluation-Confidence in Evidence from Reviews of Qualitative Research approach.
resultsSeven studies involving 115 individuals at-risk of developing RA were included. Three major themes (seven subthemes) were identified: understanding the risk of developing RA (knowledge of RA and identification of potential risk factors); preventive interventions to reduce the risk of developing RA (understanding the value and role of preventive interventions, and engagement with preventive interventions); and perceptions of predictive testing for RA (benefits of predictive testing, decision to undertake predictive testing and concerns about predictive testing). Moderate confidence in most review findings was evident.
conclusionWhile there are clear benefits in informing individuals at-risk of RA about their risk following predictive testing and offering preventive treatment, there are potential barriers to engagement, intensified by the burden of uncertainty. Identification of the optimum approaches for presenting risk information, including the risks and benefits of engaging with preventive interventions, is urgently needed to support individuals at-risk of RA in their decision making. PROSPERO REGISTRATION NUMBER: CRD42021236034.
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