Evidence map›Paper›PMID 34749994›Full record

Trial reportBritish journal of anaesthesia2022

High-dose steroids in high pain responders undergoing total knee arthroplasty: a randomised double-blind trial.

Niklas I Nielsen, Henrik Kehlet, Kirill Gromov, Anders Troelsen, Henrik Husted, Claus Varnum, Per Kjærsgaard-Andersen, Lasse E Rasmussen, Lina Pleckaitiene, Nicolai B Foss

2 registry-linked trialsOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03763734 phase4completednot on this map

High-Dose Steroids in High Pain Responders Undergoing Total Knee-arthroplasty: A Randomized Double Blinded Controlled Trial

TypeinterventionalSponsorCopenhagen University Hospital, HvidovreRan2019 to 2021Enrolled88ConditionsPostoperative Pain, Postoperative Nausea and Vomiting, Knee Osteoarthritis, Perioperative/Postoperative ComplicationsArmsDexamethasone
NCT05510947 completednot on this map

Acute Postoperative Pain and Catastrophizing in Patients Undergoing Unicompartmental Knee Arthroplasty - A Prospective, Observational, Single-center, Cohort Study

TypeobservationalSponsorCopenhagen University Hospital, HvidovreRan2022 to 2023Enrolled146ConditionsPost Operative Pain
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Niklas I NielsenDepartment of Anaesthesiology, Copenhagen University, Hvidovre Hospital, Copenhagen, Denmark. Electronic address: Niklas.Ingemann.Nielsen@regionh.dk.
Henrik KehletSection of Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Kirill GromovDepartment of Orthopaedic Surgery, Copenhagen University, Hvidovre Hospital, Copenhagen, Denmark.
Anders TroelsenDepartment of Orthopaedic Surgery, Copenhagen University, Hvidovre Hospital, Copenhagen, Denmark.
Henrik HustedDepartment of Orthopaedic Surgery, Copenhagen University, Hvidovre Hospital, Copenhagen, Denmark.
Claus VarnumDepartment of Orthopaedic Surgery, Lillebaelt Hospital, Vejle, Denmark.
Per Kjærsgaard-AndersenDepartment of Orthopaedic Surgery, Lillebaelt Hospital, Vejle, Denmark.
Lasse E RasmussenDepartment of Orthopaedic Surgery, Lillebaelt Hospital, Vejle, Denmark.
Lina PleckaitieneDepartment of Anaesthesiology, Lillebaelt Hospital, Vejle, Denmark.
Nicolai B FossDepartment of Anaesthesiology, Copenhagen University, Hvidovre Hospital, Copenhagen, Denmark.
Hvidovre Hospital · DKLillebaelt Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal knee arthroplasty (TKA) is associated with moderate-to-severe postoperative pain despite multimodal opioid-sparing analgesia. Pain catastrophising or preoperative opioid therapy is associated with increased postoperative pain. Preoperative glucocorticoid improves pain after TKA, but dose-finding studies and benefit in high pain responders are lacking.

methodsA randomised double-blind controlled trial with preoperative high-dose intravenous dexamethasone 1 mg kg

resultsModerate-to-severe pain when walking 24 h postoperatively was reduced (high dose vs intermediate dose, 49% vs 79%; P<0.01), along with pain at leg raise at 24 and 48 h (14% vs 29%, P=0.02 and 12% vs 31%, P=0.03, respectively). C-reactive protein was reduced in the high-dose group at both 24 and 48 h (both P<0.01). Quality of Recovery-15 was also improved (P<0.01).

conclusionsWhen compared with preoperative dexamethasone 0.3 mg kg CLINICAL

trial registrationNCT03763734.

Indexed as

AgedAged, 80 and overAnalgesics, OpioidArthroplasty, Replacement, KneeC-Reactive ProteinDexamethasoneDose-Response Relationship, DrugDouble-Blind MethodFemaleGlucocorticoidsHumansMaleMiddle AgedPain MeasurementPostoperative PainPreoperative CareAnalgesics, OpioidC-Reactive ProteinDexamethasoneGlucocorticoidsanaesthesiadexamethasonefast-track surgeryhigh-dose steroidshigh pain respondersmultimodal analgesiapostoperative paintotal knee arthroplasty

Identifiers

PMID34749994
PMCPMC8787770
OpenAlexW3212327651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.