Evidence map›Paper›PMID 34749800›Full record

ArticleAlzheimer's research & therapy2021

N-Methyl-D-aspartate (NMDA) and cannabinoid CB

Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S Contestí, Carlos A Saura, Rafael Franco, Gemma Navarro

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. The Interplay Between CBInternational journal of molecular sciences · 2025
    Article
  3. Cannabinoid CBACS pharmacology & translational science · 2025
    Article
  4. Review
  5. Article
  6. Future Perspectives of NMDAR in CNS Disorders.Molecules (Basel, Switzerland) · 2025
    Review
  7. Review
  8. Review
  9. The Expression and Functionality of CBInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rafael Rivas-SantistebanCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain.
Alejandro LilloInstitut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.
Jaume LilloCentro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain.
Joan-Biel RebassaDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.
Joan S ContestíDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.
Carlos A SauraInstitut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.
Rafael Franco *Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain. rfranco123@gmail.com.ORCID 0000-0003-2549-4919
Gemma Navarro *Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, Madrid, Spain. g.navarro@ub.edu.
Biomedical Research Networking Center on Neurodegenerative Diseases · ESUniversitat Autònoma de Barcelona · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cannabinoid CB

methodsImmunocytochemistry was used to analyze the colocalization between CB

resultsIn a heterologous system, we identified CB

conclusionsThe results indicate a negative cross-talk in CB

Indexed as

CannabinoidsMicrogliaReceptors, CannabinoidReceptors, N-Methyl-D-AspartateAnimalsHippocampusHumansMiceNeuronsN-MethylaspartateCannabinoidsN-MethylaspartateReceptors, CannabinoidReceptors, N-Methyl-D-AspartateAlzheimer’s diseaseExcitotoxicityG-protein-coupled receptorsNeuroprotection

Identifiers

PMID34749800
PMCPMC8576920
OpenAlexW3213650764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.