ArticleArthritis research & therapy2021
First-year follow-up of children with chronic nonbacterial osteomyelitis-an analysis of the German National Pediatric Rheumatologic Database from 2009 to 2018.
Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Efficacy and Safety of Bisphosphonates in Chronic Non-bacterial Osteomyelitis of the Mandible: A Systematic Review.Calcified tissue international · 2025Pooled it
- HLA-B*27 is associated with CNO in a European cohort.Pediatric rheumatology online journal · 2023Pooled it
- Pamidronate for pain in adult chronic nonbacterial osteitis: protocol of a randomized, double-blind, placebo-controlled trial.JBMR plus · 2024Trial
- Chronic nonbacterial osteomyelitis and inflammatory bowel disease in children: A French national cohort.Journal of pediatric gastroenterology and nutrition · 2026Article
- How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis.Paediatric drugs · 2026Review
- Chronic Nonbacterial Osteomyelitis in Latvia from 2014 to 2025: Case Series.Medicina (Kaunas, Lithuania) · 2026Article
- Atypical and less-common imaging presentations of chronic nonbacterial osteitis in children: a pictorial review.Pediatric radiology · 2026Review
- [Chronic nonbacterial osteomyelitis/osteitis of childhood and adolescence].Zeitschrift fur Rheumatologie · 2026Review
- Chronic Recurrent Multifocal Osteomyelitis: A Review of 80 Cases in Chinese Children.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2026Review
- Pediatric acute leukemia mimicking osteomyelitis: clinical and MRI features.Frontiers in oncology · 2026Article
- Assessing Disease Activity in Pediatric Chronic Nonbacterial Osteomyelitis: A Proposal for Composite Scoring, Including Inactivity Measures.ACR open rheumatology · 2025Article
- The impact of sarcopenia on the progression of chronic non-bacterial osteomyelitis.Insights into imaging · 2025Article
- Chronic non-bacterial osteomyelitis in children- five-year standardized follow-up of a prospective observational cohort in the pre-biological era.Pediatric rheumatology online journal · 2025Observational
- Subclinical Enthesitis in Children with Chronic Nonbacterial Osteomyelitis.Turkish archives of pediatrics · 2025Article
- Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study.Pediatric rheumatology online journal · 2025Article
- Clinical Presentation and Course of Pulmonary Involvement in Chronic Nonbacterial Osteomyelitis.ACR open rheumatology · 2025Article
- Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort.Therapeutic advances in musculoskeletal disease · 2025Article
- Update on the diagnosis and treatment of CNO in children: a clinician's perspective.European journal of pediatrics · 2024Review
- Preferential involvement of the pelvis and hips along with active sacroiliitis in chronic nonbacterial osteomyelitis: MRI of 97 patients from a single tertiary referral center.European radiology · 2024Article
- Musculoskeletal symptoms and their impact on health-related quality of life in chronic nonbacterial osteomyelitis patients.Pediatric rheumatology online journal · 2024Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the first-year features of patients with chronic nonbacterial osteomyelitis (CNO).
methodsPatients with a diagnosis of CNO, disease duration of under 13 months, and first registration in the German National Pediatric Rheumatologic Database (NPRD) between 2009 and 2018 were included in this cross-sectional analysis.
resultsOf 774 documented patients, 62.8% were female, and all patients had a median age of 11 years. The most affected clinical sites were the tibia (29.7%), pelvis (28.0%), and femur (27.8%). HLA-B27 was positive in 48 of 314 analyzed patients (15.3%). In 406 patients, an X-ray was performed at the first visit; X-ray results showed osteosclerosis/-lysis in 34.0% and hyperostosis in 14.5% of the patients. MRI scans (focal and whole-body scans) were performed in 648 patients, and 81.5% showed a positive TIRM/STIR signal. A total of 84.7% of the patients were administered nonsteroidal anti-inflammatory drugs, 9.6% were administered oral glucocorticoids, 10.8% were administered disease-modifying anti-rheumatic drugs (DMARDs), and 6.1% were administered bisphosphonates. An evaluation of the patient's questionnaire showed an overall well-being (NRS 0-10) of 2.0. The PedCNO disease "activity" score revealed a 70% improvement in variables in 43% of patients in the initial 1-year follow-up. Copresentation with diagnostic criteria of pediatric enthesitis-related arthritis was rare.
conclusionTo our knowledge, the NPRD cohort seemed to be the largest cohort of children and adolescents suffering from CNO worldwide. Most patients were treated effectively with NSAIDs, and only a small group of patients was administered additional medication. The patient-defined measures of disease activity had a moderate impact on patients' daily lives.
trial registrationNot applicable.
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