ArticleCritical care (London, England)2021
The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04401254 (The Coronavirus Disease 2019 - Recovery Study), which is not on this map. Cited by 57 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Coronavirus Disease 2019 - Recovery Study
Who cites it
57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies.Health and quality of life outcomes · 2025Pooled it
- Work ability and return-to-work of patients with post-COVID-19: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies.Aging clinical and experimental research · 2024Pooled it
- What are the long-term holistic health consequences of COVID-19 among survivors? An umbrella systematic review.Journal of medical virology · 2022Pooled it
- Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis.Infection · 2022Pooled it
- Social Determinants of Health and Long‑Term Joblessness Among Severe COVID‑19 Survivors: Secondary Analysis of a Nationwide 2‑Year Prospective Cohort (COVID-19 Recovery Study II).Critical care explorations · 2026Observational
- Physiological barriers to oral intake in survivors of critical illness: A scoping review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Rinaldo Bellomo and the evolution of critical care survivorship.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- The 1-Year Functional Recovery From Severe COVID-19 in a Swedish Working-Age Cohort.Acta anaesthesiologica Scandinavica · 2025Article
- Predicting work ability impairment in post COVID-19 patients: a machine learning model based on clinical parameters.Infection · 2025Article
- Health-related quality of life, physical and mental capacity at one year follow up of COVID-19 ICU patients: A prospective cohort study.Journal of patient-reported outcomes · 2025Article
- Consumer Experience of an Australian Multidisciplinary Long COVID Clinic That Incorporates Personalised Exercise Prescription: A Qualitative Analysis.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- How long is Long-COVID? Symptomatic improvement between 12 and 18 months in a prospective cohort study.BMJ military health · 2025Article
- Functioning of post-COVID-19 patients: a cross-sectional study at the outpatient clinic for long-term effects.Scandinavian journal of primary health care · 2025Article
- Benzodiazepine and z-drug prescribing in critical care survivors and the risk of rehospitalisation or death due to falls/trauma and due to any cause: a retrospective matched cohort study using the UK Clinical Practice Research Datalink.Intensive care medicine · 2025Article
- Long-Term Disabilities in ICU Survivors of COVID-19.Respiratory care · 2024Article
- Disability Following Critical Illness Due to COVID-19-Where to Next?Respiratory care · 2024Article
- Article
- Outcome Measures to Evaluate Functional Recovery in Survivors of Respiratory Failure: A Scoping Review.CHEST critical care · 2024Article
- Enhancing quality of life in severe post-COVID-19 survivors through multidisciplinary care.ERJ open research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 19 institutions in 2 countries.
Funding
Abstract
backgroundThere are few reports of new functional impairment following critical illness from COVID-19. We aimed to describe the incidence of death or new disability, functional impairment and changes in health-related quality of life of patients after COVID-19 critical illness at 6 months.
methodsIn a nationally representative, multicenter, prospective cohort study of COVID-19 critical illness, we determined the prevalence of death or new disability at 6 months, the primary outcome. We measured mortality, new disability and return to work with changes in the World Health Organization Disability Assessment Schedule 2.0 12L (WHODAS) and health status with the EQ5D-5L
resultsOf 274 eligible patients, 212 were enrolled from 30 hospitals. The median age was 61 (51-70) years, and 124 (58.5%) patients were male. At 6 months, 43/160 (26.9%) patients died and 42/108 (38.9%) responding survivors reported new disability. Compared to pre-illness, the WHODAS percentage score worsened (mean difference (MD), 10.40% [95% CI 7.06-13.77]; p < 0.001). Thirteen (11.4%) survivors had not returned to work due to poor health. There was a decrease in the EQ-5D-5L
conclusionsAt six months after COVID-19 critical illness, death and new disability was substantial. Over a third of survivors had new disability, which was widespread across all areas of functioning. Clinical trial registration NCT04401254 May 26, 2020.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.