Evidence map›Paper›PMID 34749663›Full record

ArticleBMC gastroenterology2021

Clinical outcomes of surgical resection versus radiofrequency ablation in very-early-stage hepatocellular carcinoma: a propensity score matching analysis.

Yuan-Chen Li, Ping-Hung Chen, Jen-Hao Yeh, Pojen Hsiao, Gin-Ho Lo, TaoQian Tan, Pin-Nan Cheng, Hung-Yu Lin, Yaw-Sen Chen, Kun-Chou Hsieh and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yuan-Chen Li *School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Ping-Hung Chen *School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Jen-Hao YehSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Pojen HsiaoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Gin-Ho LoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
TaoQian TanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Pin-Nan ChengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Hung-Yu LinSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Yaw-Sen ChenSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Kun-Chou Hsieh *Department of Surgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. hkcjoe@gmail.com.
Pei-Min Hsieh *School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Chih-Wen Lin *School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan. lincw66@gmail.com.
I-Shou University · TWE-Da Hospital · TWNational Cheng Kung University Hospital · TW

Funding

E-Da Hospital EDAHP108036E-Da Hospital EDAHP108037E-Da Hospital EDAHP108038E-Da Hospital EDAHP110035E-Da Hospital EDAHP110036E-Da Hospital EDAHP110040E-Da Hospital EDAHS109004Ministry of Science and Technology, Taiwan 108-2314-B-214-006-MY2Ministry of Science and Technology, Taiwan 109-2811-B-214-500Ministry of Science and Technology, Taiwan 110-2314-B-214-004-MY1National Cheng Kung University Hospital NCKUEDA10803National Cheng Kung University Hospital NCKUEDA10916
6 · The paper itself

Abstract

backgroundThe detection rate of Barcelona Clinic Liver Cancer (BCLC) very-early-stage hepatocellular carcinoma (HCC) is increasing because of advances in surveillance and improved imaging technologies for high-risk populations. Surgical resection (SR) and radiofrequency ablation (RFA) are both first-line treatments for very-early-stage HCC, but the differences in clinical outcomes between patients treated with SR and RFA remain unclear. This study investigated the prognosis of SR and RFA for very-early-stage HCC patients with long-term follow-up.

methodsThis study was retrospectively collected data on the clinicopathological characteristics, overall survival (OS), and disease-free survival (DFS) of 188 very-early-stage HCC patients (≤ 2 cm single HCC). OS and DFS were analyzed using the Kaplan-Meier method and Cox regression analysis. Propensity score matching (PSM) analysis was performed.

resultsOf the 188 HCC patients, 103 received SR and 85 received RFA. The median follow-up time was 56 months. The SR group had significantly higher OS than the RFA group (10-year cumulative OS: 55.2% and 31.3% in the SR and RFA groups, respectively). No statistically significant difference was observed in DFS between the SR and RFA groups (10-year cumulative DFS: 45.9% and 32.6% in the SR and RFA groups, respectively). After PSM, the OS in the SR group remained significantly higher than that in the RFA group (10-year cumulative OS: 54.7% and 42.2% in the SR and RFA groups, respectively). No significant difference was observed in DFS between the SR and RFA groups (10-year cumulative DFS: 43.0% and 35.4% in the SR and RFA groups, respectively). Furthermore, in the multivariate Cox regression analysis, treatment type (hazard ratio (HR): 0.54, 95% confidence interval (CI): 0.31-0.95; P = 0.032) and total bilirubin (HR: 1.92; 95% CI: 1.09-3.41; P = 0.025) were highly associated with OS. In addition, age (HR: 2.14, 95% CI: 1.36-3.36; P = 0.001) and cirrhosis (HR: 1.79; 95% CI: 1.11-2.89; P = 0.018) were strongly associated with DFS.

conclusionFor patients with very-early-stage HCC, SR was associated with significantly higher OS rates than RFA. However, no significant difference was observed in DFS between the SR and RFA groups.

Indexed as

Carcinoma, HepatocellularCatheter AblationLiver NeoplasmsRadiofrequency AblationHepatectomyHumansNeoplasm Recurrence, LocalPropensity ScoreRetrospective StudiesTreatment OutcomeDisease-free survivalOverall survivalRadiofrequency ablationSurgical proceduresVery-early-stage hepatocellular carcinoma

Identifiers

PMID34749663
PMCPMC8574049
OpenAlexW3213928212

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.