ArticleGenetics, selection, evolution : GSE2021
VarGoats project: a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity.
Article in Genetics, selection, evolution : GSE, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Genomic solutions to metadata challenges: a case study on the 1000 Bull Genomes Project.Genetics, selection, evolution : GSE · 2026Article
- Identification of a recessiveVeterinary and animal science · 2026Article
- A genomic approach for accurate identification of closely related species with next-generation sequencing samples.Scientific reports · 2026Article
- Ecology and demographic structure of an extinct ibex population in late Upper Palaeolithic Italian Alps.Scientific reports · 2026Article
- Genome-wide in-silico identification and characterization of LTR retrotransposons in domestic goat (Capra hircus).Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Advancements in Animal Breeding: From Mendelian Genetics to Machine Learning.International journal of molecular sciences · 2025Review
- Paleogenomic evidence on the temporal continuity of indigenous goat exploitation in the Canary Islands.iScience · 2025Article
- Inferring Domestic Goat Demographic History Through Ancient Genome Imputation.Genome biology and evolution · 2025Article
- A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits.BMC genomics · 2025Article
- Genome landscape and genetic architecture of recombination in domestic goats (Capra hircus).Genetics, selection, evolution : GSE · 2025Article
- Genome-wide analysis provides insight into the genetic diversity and adaptability of Kazakhstan local goats.Scientific reports · 2025Article
- Myochromella unveiled: exploring its global distribution through a public database of amplicons.BMC microbiology · 2025Article
- The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project.Nature genetics · 2025Review
- Clinical, Histological and Genetic Characterisation of a Disorder of Sexual Development in a Pygmy Goat.Animals : an open access journal from MDPI · 2025Article
- The goat pan-genome reveals patterns of gene loss during domestication.Journal of animal science and biotechnology · 2024Article
- One Copy Number Variation within the Angiopoietin-1 Gene Is Associated with Leizhou Black Goat Meat Quality.Animals : an open access journal from MDPI · 2024Article
- Genetic Diversity, Population Structure and Selection Signature in Begait Goats Revealed by Whole-Genome Sequencing.Animals : an open access journal from MDPI · 2024Article
- Characterization of heterozygosity-rich regions in Italian and worldwide goat breeds.Scientific reports · 2024Article
- Genetic diversity, population structure and kinship relationships highlight the environmental influence on Uganda's indigenous goat populations.Frontiers in genetics · 2024Article
- TAGADA: a scalable pipeline to improve genome annotations with RNA-seq data.NAR genomics and bioinformatics · 2023Article
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Authors and funding
24 authors at 11 institutions in 7 countries.
Funding
Abstract
backgroundSince their domestication 10,500 years ago, goat populations with distinctive genetic backgrounds have adapted to a broad variety of environments and breeding conditions. The VarGoats project is an international 1000-genome resequencing program designed to understand the consequences of domestication and breeding on the genetic diversity of domestic goats and to elucidate how speciation and hybridization have modeled the genomes of a set of species representative of the genus Capra.
findingsA dataset comprising 652 sequenced goats and 507 public goat sequences, including 35 animals representing eight wild species, has been collected worldwide. We identified 74,274,427 single nucleotide polymorphisms (SNPs) and 13,607,850 insertion-deletions (InDels) by aligning these sequences to the latest version of the goat reference genome (ARS1). A Neighbor-joining tree based on Reynolds genetic distances showed that goats from Africa, Asia and Europe tend to group into independent clusters. Because goat breeds from Oceania and Caribbean (Creole) all derive from imported animals, they are distributed along the tree according to their ancestral geographic origin.
conclusionsWe report on an unprecedented international effort to characterize the genome-wide diversity of domestic goats. This large range of sequenced individuals represents a unique opportunity to ascertain how the demographic and selection processes associated with post-domestication history have shaped the diversity of this species. Data generated for the project will also be extremely useful to identify deleterious mutations and polymorphisms with causal effects on complex traits, and thus will contribute to new knowledge that could be used in genomic prediction and genome-wide association studies.
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