Evidence map›Paper›PMID 34749525›Full record

ArticlemBio2021

Proximity-Labeling Reveals Novel Host and Parasite Proteins at the

Alicja M Cygan, Pierre M Jean Beltran, Alma G Mendoza, Tess C Branon, Alice Y Ting, Steven A Carr, John C Boothroyd

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Dense granule proteins: key mediators ofFrontiers in medicine · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Proteome changes duringFrontiers in cellular and infection microbiology · 2025
    Article
  10. Article
  11. SPARK regulates AGC kinases central to thebioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Susceptibility ofmBio · 2024
    Article
  14. Proteomics Applications inPathogens (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alicja M CyganDepartment of Microbiology and Immunology, Stanford School of Medicine, Stanford California, USA.
Pierre M Jean BeltranBroad Institutegrid.66859.34 of MIT and Harvard, Cambridge, Massachusetts, USA.
Alma G MendozaDepartment of Microbiology and Immunology, Stanford School of Medicine, Stanford California, USA.
Tess C BranonDepartment of Chemistry, Stanford Universitygrid.168010.e, Stanford, California, USA.
Alice Y TingDepartment of Chemistry, Stanford Universitygrid.168010.e, Stanford, California, USA.
Steven A CarrBroad Institutegrid.66859.34 of MIT and Harvard, Cambridge, Massachusetts, USA.
John C BoothroydDepartment of Microbiology and Immunology, Stanford School of Medicine, Stanford California, USA.ORCID 0000-0001-9719-745X
Stanford Medicine · USBroad Institute · USStanford University · US

Funding

Mapping protein communication between organs in homeostasis and diseaseR01DK121409 · NIDDK · HARVARD MEDICAL SCHOOL · PI CARR, STEVEN A, MCMAHON, ANDREW P. · 2018 to 2022
$8.3M
Toxoplasma Rhoptry FunctionR01AI021423 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 1985 to 2018
$7.8M
Identifying The Machinery That Translocates Toxoplasma Effectors Into The Host CellR01AI129529 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 2018 to 2021
$2.2M
Molecular Mechanisms of the Multi-Organ Response and Adaptation to ExerciseF32HL154711 · NHLBI · BROAD INSTITUTE, INC. · PI JEAN BELTRAN, PIERRE MICHEL · 2020 to 2021
$92k
NHLBI NIH HHS F32 HL154711NIAID NIH HHS R01 AI021423NIAID NIH HHS R01 AI129529NIDDK NIH HHS R01 DK121409
6 · The paper itself

Abstract

Toxoplasma gondii is a ubiquitous, intracellular parasite that envelops its parasitophorous vacuole with a protein-laden membrane (PVM). The PVM is critical for interactions with the infected host cell, such as nutrient transport and immune defense. Only a few parasite and host proteins have so far been identified on the host-cytosolic side of the

Indexed as

Apoptosis Regulatory ProteinsCalcium-Binding ProteinsCell Cycle ProteinsDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportHost-Parasite InteractionsHumansIntracellular MembranesMembrane ProteinsProtein TransportProtozoan ProteinsReceptors, ChemokineToxoplasmaToxoplasmosisVacuolesApoptosis Regulatory ProteinsCalcium-Binding ProteinsCC2D1A protein, humanCell Cycle ProteinsDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportMembrane ProteinsMOSPD2 protein, humanPDCD6IP protein, humanPDCD6 protein, humanProtozoan ProteinsReceptors, Chemokineproximity-labelingquantitative proteomicsToxoplasma

Identifiers

PMID34749525
PMCPMC8576527
OpenAlexW3211913656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.