Evidence map›Paper›PMID 34749363›Full record

ArticleActa haematologica

Unusually High Prevalence of Stroke and Cerebral Vasculopathy in Hemoglobin SC Disease: A Retrospective Single Institution Study.

Bindu Kanathezhath Sathi, Yilin Yoshida, Michael Raymond Weaver, Lila S Nolan, Barbara Gruner, Vinod Balasa, Talissa Altes, Carlos Leiva-Salinas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta haematologica. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Bindu Kanathezhath SathiPediatric Hematology Oncology, Valley Children's Hospital, University of San Francisco-Fresno Program, Madera, California, USA.
Yilin YoshidaDepartment of Internal Medicine, Tulane University, New Orleans, Louisiana, USA.
Michael Raymond WeaverDepartment of Child Health, University of Missouri, Columbia, South Carolina, USA.
Lila S NolanDepartment of Child Health, University of Missouri, Columbia, South Carolina, USA.
Barbara GrunerDepartment of Child Health, University of Missouri, Columbia, South Carolina, USA.
Vinod BalasaPediatric Hematology Oncology, Valley Children's Hospital, University of San Francisco-Fresno Program, Madera, California, USA.
Talissa AltesDepartment of Child Health, University of Missouri, Columbia, South Carolina, USA.
Carlos Leiva-SalinasDepartment of Radiology, University of Missouri, Columbia, South Carolina, USA.
University of Missouri · USChildren's Hospital Central California · USTulane University · USUniversity of Missouri Health System · USUniversity of San Francisco · USUniversity of South Florida · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnlike homozygous hemoglobin SS (HbSS) disease, stroke is a rare complication in hemoglobin SC (HbSC) disease. However, recent studies have demonstrated a high prevalence of silent stroke in HbSC disease. The factors associated with stroke and cerebral vasculopathy in the HbSC population are unknown.

methodsWe conducted a retrospective study of all patients with sickle cell disease treated at the University of Missouri, Columbia, over an 18-year period (2000-2018). The goal of the study was to characterize the silent, overt stroke, and cerebral vasculopathy in HbSC patients and compare them to patients with HbSS and HbS/β thalassemia1 (thal) in this cohort. We also analyzed the laboratory and clinical factors associated with stroke and cerebral vasculopathy in the HbSC population.

resultsOf the 34 HbSC individuals, we found that the overall prevalence of stroke and cerebral vasculopathy was 17.7%. Only females had evidence of stroke or cerebral vasculopathy in our HbSC cohort (33.3%, p = 0.019). Time-averaged means of maximum velocities were lower in the HbSC group than the HbSS group and did not correlate with stroke outcome. Among HbSC individuals, those with stroke and cerebral vasculopathy had a marginally higher serum creatinine than those without these complications (0.77 mg/dL vs. 0.88 mg/dL, p = 0.08). Stroke outcome was associated with recurrent vaso-occlusive pain crises (Rec VOCs) (75 vs. 25%, p = 0.003) in HbSC patients. The predominant cerebrovascular lesions in HbSC included microhemorrhages and leukoencephalopathy.

conclusionThere is a distinct subset of individuals with HbSC who developed overt, silent stroke, and cerebral vasculopathy. A female predominance and association with Rec VOCs were identified in our cohort; however, larger clinical trials are needed to identify and confirm specific clinical and laboratory markers associated with stroke and vasculopathy in HbSC disease.

Indexed as

Anemia, Sickle CellHemoglobin SC DiseaseStrokeFemaleHumansPrevalenceRetrospective StudiesCerebral vasculopathyHemoglobin SC diseaseSilent cerebral infarctionStroke

Identifiers

PMID34749363
PMCPMC9116597
OpenAlexW3213808900

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.