Evidence map›Paper›PMID 34749232›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021

Sensory tricks modulate corticocortical and corticomuscular connectivity in cervical dystonia.

Sang Wook Lee, Hyun Joo Cho, Hae-Won Shin, Mark Hallett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sang Wook LeeDepartment of Biomedical Engineering, Catholic University of America, Washington, DC, USA; Center for Applied Biomechanics and Rehabilitation Research, MedStar National Rehabilitation Hospital, Washington, DC, USA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
Hyun Joo ChoHuman Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.
Hae-Won ShinHuman Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA. Electronic address: hallettm@ninds.nih.gov.
National Institutes of Health · USMedStar National Rehabilitation Hospital · US

Funding

Pathophysiology of Basal Ganglia DisordersZ01NS003031 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2007 to 2008
$4.4M
Intramural NIH HHS Z01 NS003031
6 · The paper itself

Abstract

objectiveTo examine interactions between cortical areas and between cortical areas and muscles during sensory tricks in cervical dystonia (CD).

methodsThirteen CD patients and thirteen age-matched healthy controls performed forewarned reaction time tasks, sensory tricks, and two tasks replicating aspects of the tricks (moving necks/arms). Control subjects mimicked sensory tricks. Corticocortical and corticomuscular coherence values were calculated from surface electrodes placed over motor, premotor, and sensory cortical areas and dystonic muscles.

resultsDuring initial preparation (after the warning stimulus), the only between-task difference was found in the γ-band corticocortical coherence (higher during tricks than during voluntary neck movements). With movements (before/after the imperative stimulus), the γ-band coherence of CD patients significantly increased during tricks but decreased during voluntary movements, while opposite trends were observed in healthy subjects. Additionally, the α- and β-band coherence decreased in healthy subjects during movements. Between the two patient subgroups (typical vs. forcible tricks), only those with typical tricks showed significant decrease in corticomuscular coherence during tricks.

conclusionsObserved changes in the corticocortical coherence suggest that sensory tricks improve cortical function, which reduces corticomuscular connectivity and the dystonia. SIGNIFICANCE: We demonstrated that sensory tricks fundamentally affect sensorimotor integration in CD, both in movement preparation and execution.

Indexed as

AdultAgedAged, 80 and overCerebral CortexFemaleHumansMaleMiddle AgedMovementMuscle, SkeletalPsychomotor PerformanceTorticollisCervical dystoniaCorticocortical coherenceCorticomuscular coherenceIntracortical connectivitySensory tricks

Identifiers

PMID34749232
PMCPMC8629937
OpenAlexW3204319906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.