Evidence map›Paper›PMID 34749005›Full record

ArticleBrain stimulation

Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease.

Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A Mills

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Khaled MoussawiDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Min Jae KimDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Sydney BaybayanDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Myles WoodDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kelly A MillsDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address: kmills16@jhmi.edu.
Johns Hopkins University · USUniversity of Pittsburgh · US

Funding

Molecular Imaging of the Nicotinic Cholinergic Receptor in Parkinson's disease (PD): Implication of for understanding the neurobiology of cognitive impairmentK23NS101096 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLS, KELLY ALEXANDER · 2017 to 2021
$1000k
TMS effects on circuit plasticity and drug seeking in mice - Diversity SupplementR00DA048085 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOUSSAWI, KHALED · 2021 to 2023
$930k
NIDA NIH HHS K99 DA048085NIDA NIH HHS R00 DA048085NINDS NIH HHS K23 NS101096
6 · The paper itself

Abstract

backgroundDeep Brain Stimulation (DBS) of the subthalamic nucleus or globus pallidus internus is used to treat the motor symptoms of Parkinson's disease. The former can worsen impulsive and compulsive behaviors after controlling for the reduction of dopaminergic medications. However, the effect of pallidal DBS on such behaviors in PD patients is less clear. OBJECTIVE/HYPOTHESIS: We hypothesized that greater stimulation spread to the pallidum with prefrontal connectivity would reduce motor impulsivity.

methodsSeven Parkinson's patients with stable globus pallidus internus DBS settings for 3 months, disease duration of 13 ± 1.3 years, and Montreal Cognitive Assessment of 26.8 ± 1.1 each had two stimulation settings defined based on reconstructions of lead placement and volume of tissue activation targeting either a dorsal or ventral position along the DBS electrode but still within the globus pallidus internus. Subjects performed a stop signal reaction time task with the DBS turned off vs. on in each of the defined stimulation settings, which was correlated with the degree of stimulation effect on pallidal subregions.

resultsA shorter distance between the volume of tissue activation and the right prefrontally-connected GPi correlated with less impulsivity on the stop signal reaction time task (r = 0.69, p < 0.05). Greater volume of tissue activation overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.

conclusionThese data can be leveraged to optimize DBS programming in PD patients with problematic impulsivity or in other disorders involving impulsive behaviors such as substance use disorders.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusGlobus PallidusHumansImpulsive BehaviorDeep brain stimulationGlobus pallidusImpulsivityParkinson's disease

Identifiers

PMID34749005
PMCPMC8816820
OpenAlexW3212093755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.