Evidence map›Paper›PMID 34748720›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Combustible and Electronic Cigarette Exposures Increase ACE2 Activity and SARS-CoV-2 Spike Binding.

Arunava Ghosh, Vishruth Girish, Monet Lou Yuan, Raymond D Coakley, Joe A Wrennall, Neil E Alexis, Erin L Sausville, Anand Vasudevan, Alexander R Chait, Jason M Sheltzer and 1 more

Abstract readLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The triple-hit hypothesis: exploring pulmonary e-cigarette, PMEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Vaping-Induced Proteolysis Causes Airway Surface Dehydration.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Article
  6. Activities Carried Out during the First COVID-19 Lockdown by Italian Citizens.International journal of environmental research and public health · 2023
    Article
  7. Article
  8. SARS-CoV-2: The Monster Causes COVID-19.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arunava GhoshUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Vishruth GirishCold Spring Harbor Laboratory Cold Spring Harbor New York.
Monet Lou YuanCold Spring Harbor Laboratory Cold Spring Harbor New York.
Raymond D CoakleyUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Joe A WrennallUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Neil E AlexisUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.
Erin L SausvilleCold Spring Harbor Laboratory Cold Spring Harbor New York.
Anand VasudevanCold Spring Harbor Laboratory Cold Spring Harbor New York.
Alexander R ChaitCold Spring Harbor Laboratory Cold Spring Harbor New York.
Jason M SheltzerCold Spring Harbor Laboratory Cold Spring Harbor New York.
Robert TarranUniversity of North Carolina at Chapel Hill Chapel Hill, North Carolina.ORCID 0000-0002-8598-2642

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
The Impact of Tobacco Exposure on the Lungs Innate Defense SystemP50HL120100 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRAN, ROBERT · 2013 to 2017
$21.0M
The effect of Inhaled Nicotine on Pulmonary SurfacesR01HL135642 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESIMER, MEHMET, TARRAN, ROBERT · 2017 to 2021
$2.9M
Identification and characterization of genomic features affecting survival duration in cancerDP5OD021385 · OD · COLD SPRING HARBOR LABORATORY · PI SHELTZER, JASON · 2015 to 2020
$2.8M
Discovering the mechanisms-of-action of mistargeted anti-cancer agentsR01CA237652 · NCI · YALE UNIVERSITY · PI SHELTZER, JASON · 2020 to 2024
$1.6M
Do E-Cigarette Users Airways Have an Altered Lipid Content?R21HL153698 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRAN, ROBERT · 2020 to 2021
$428k
American Cancer Society Research American Cancer Society Research Scholar GrantNCI NIH HHS P30 CA045508NCI NIH HHS R01 CA237652New York Community Trust New York Community Trust GrantNHLBI NIH HHS P50 HL120100NHLBI NIH HHS R01 HL135642NHLBI NIH HHS R21 HL153698NIH/Food and Drug Administration HL120100NIH/Food and Drug Administration HL153698NIH HHS 1DP5OD021385NIH HHS DP5 OD021385NIH HHS R01CA237652NIH/NHLBI HL135642
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAngiotensin-Converting Enzyme 2Cigarette SmokingCross-Sectional StudiesHumansProtein BindingSARS-CoV-2Spike Glycoprotein, CoronavirusVapingAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID34748720
PMCPMC8865588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.