ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Age- and Sex-Dependent Changes of Free Circulating Blood Metabolite and Lipid Abundances, Correlations, and Ratios.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Sex Differences in Omega-3 and Omega-6 PUFA Status: A Systematic Review and Meta-analysis of Cross-Sectional Comparisons.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Differences in plasma metabolome between non-Hispanic White and non-Hispanic Black women.BMC medicine · 2025Article
- Article
- Reference intervals for cardiometabolic risk factors in China: a national multicenter cross-sectional study on an adult population sample.Cardiovascular diagnosis and therapy · 2024Article
- Better Life's Essential 8 contributes to slowing the biological aging process: a cross-sectional study based on NHANES 2007-2010 data.Frontiers in public health · 2024Article
- Twelve Weeks of High-Intensity Interval Training Alters Adipose Tissue Gene Expression but Not Oxylipin Levels in People with Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2023Article
- Large-Scale metabolomics: Predicting biological age using 10,133 routine untargeted LC-MS measurements.Aging cell · 2023Article
- Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan.Metabolites · 2023Article
- Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions.Experimental gerontology · 2023Review
- Metabolomics Captures the Biological Signatures of Aging and Health Span and Identifies Pathway Targets for Intervention.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Targeted metabolomics analysis of amino acids and acylcarnitines as risk markers for diabetes by LC-MS/MS technique.Scientific reports · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated how the concentrations, pairwise correlations and ratios of 202 free circulating blood metabolites and lipids vary with age in a panel of n = 1 882 participants with an age range from 48 to 94 years. We report a statistically significant sex-dependent association with age of a panel of metabolites and lipids involving, in women, linoleic acid, α-linoleic acid, and carnitine, and, in men, monoacylglycerols and lysophosphatidylcholines. Evaluating the association of correlations among metabolites and/or lipids with age, we found that phosphatidylcholines correlations tend to have a positive trend associated with age in women, and monoacylglycerols and lysophosphatidylcholines correlations tend to have a negative trend associated with age in men. The association of ratio between molecular features with age reveals that decanoyl-l-carnitine/lysophosphatidylcholine ratio in women "decrease" with age, while l-carnitine/phosphatidylcholine and l-acetylcarnitine/phosphatidylcholine ratios in men "increase" with age. These results suggest an age-dependent remodeling of lipid metabolism that induces changes in cell membrane bilayer composition and cell cycle mechanisms. Furthermore, we conclude that lipidome is directly involved in this age-dependent differentiation. Our results demonstrate that, using a comprehensive approach focused on the changes of concentrations and relationships of blood metabolites and lipids, as expressed by their correlations and ratios, it is possible to obtain relevant information about metabolic dynamics associated with age.
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