Evidence map›Paper›PMID 34748385›Full record

ArticleAntimicrobial agents and chemotherapy2022

Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis.

Cindy X Zhang, Melissa S Love, Case W McNamara, Victor Chi, Ashley K Woods, Sean Joseph, Deborah A Schaefer, Dana P Betzer, Michael W Riggs, Pui-Ying Iroh Tam and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Therapeutic potential of platelet rich plasma against experimentalJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Clofazimine for the treatment of tuberculosis.Frontiers in pharmacology · 2023
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Cindy X ZhangDepartment of Pharmaceutics, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Melissa S LoveCalibr, The Scripps Research Institute, La Jolla, California, USA.
Case W McNamaraCalibr, The Scripps Research Institute, La Jolla, California, USA.
Victor ChiCalibr, The Scripps Research Institute, La Jolla, California, USA.
Ashley K WoodsCalibr, The Scripps Research Institute, La Jolla, California, USA.
Sean JosephCalibr, The Scripps Research Institute, La Jolla, California, USA.
Deborah A SchaeferSchool of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizonagrid.134563.6, Tucson, Arizona, USA.
Dana P BetzerSchool of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizonagrid.134563.6, Tucson, Arizona, USA.
Michael W RiggsSchool of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizonagrid.134563.6, Tucson, Arizona, USA.
Pui-Ying Iroh TamMalawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Wesley C Van VoorhisDepartment of Medicine, University of Washingtongrid.34477.33, Seattle, Washington, USA.ORCID 0000-0001-6141-2015
Samuel L M ArnoldDepartment of Pharmaceutics, University of Washingtongrid.34477.33, Seattle, Washington, USA.ORCID 0000-0001-8290-2347
Scripps Research Institute · USUniversity of Arizona · USUniversity of Washington · USUniversity of Liverpool · GB

Funding

Optimization of Lead BKIs for Cryptosporidiosis TherapyR01AI155412 · NIAID · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2021 to 2025
$4.1M
NIAID NIH HHS R01 AI155412
6 · The paper itself

Abstract

Infection with

Indexed as

Antiprotozoal AgentsCryptosporidiosisCryptosporidiumAdultChildClofazimineDiarrheaHumansAntiprotozoal AgentsClofaziminecryptosporidiosisCryptosporidiumgastrointestinalgastrointestinal infectioninfectious diseasespharmacodynamicspharmacokineticsPK/PD

Identifiers

PMID34748385
PMCPMC8765308
OpenAlexW3211491054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.