Evidence map›Paper›PMID 34748384›Full record

ArticleAntimicrobial agents and chemotherapy2022

Telmisartan Restricts Chikungunya Virus Infection

Saikat De, Prabhudutta Mamidi, Soumyajit Ghosh, Supriya Suman Keshry, Chandan Mahish, Sweta Smita Pani, Eshna Laha, Amrita Ray, Ankita Datey, Sanchari Chatterjee and 6 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  6. Network Pharmacology, Molecular Docking andCurrent computer-aided drug design · 2025
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  12. Analysis of the anti-PCV2 mechanism ofFrontiers in microbiology · 2024
    Article
  13. Article
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  15. Review
  16. Article
  17. Article
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  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Saikat DeInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.ORCID 0000-0003-2028-0428
Prabhudutta Mamidi *Institute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Soumyajit Ghosh *Institute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Supriya Suman KeshryInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Chandan MahishSchool of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India.
Sweta Smita PaniInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Eshna LahaInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Amrita RayInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Ankita DateyInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Sanchari ChatterjeeInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Sharad SinghInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.
Tathagata MukherjeeSchool of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India.
Somlata KhamaruSchool of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India.
Subhasis ChattopadhyaySchool of Biological Sciences, National Institute of Science Education and Research, HBNI, Bhubaneswar, India.
Bharat Bhusan SubudhiSchool of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, India.
Soma ChattopadhyayInstitute of Life Sciencesgrid.418782.0, Bhubaneswar, India.ORCID 0000-0001-8378-1014
Institute of Life Sciences · INNational Institute of Science Education and Research · INRegional Centre for Biotechnology · INSiksha O Anusandhan University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya virus (CHIKV) has reemerged as a global public health threat. The inflammatory pathways of the renin-angiotensin system (RAS) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) are usually involved in viral infections. Thus, telmisartan (TM), which is known to block the angiotensin 1 (AT1) receptor and activate PPAR-γ, was investigated for activity against CHIKV. The anti-CHIKV effect of TM was investigated

Indexed as

Chikungunya FeverMAP Kinase Signaling SystemMitogen-Activated Protein KinasesPPAR gammaReceptor, Angiotensin, Type 1AnimalsChlorocebus aethiopsLeukocytes, MononuclearMiceMice, Inbred C57BLTelmisartanVero CellsMitogen-Activated Protein KinasesPPAR gammaReceptor, Angiotensin, Type 1TelmisartanAT1Chikungunya virusdrug repurposingPPAR-γtelmisartan

Identifiers

PMID34748384
PMCPMC8765259
OpenAlexW3212140265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.