Evidence map›Paper›PMID 34748383›Full record

Observational studyAntimicrobial agents and chemotherapy2022

Thomas H McConville, Eloise D Austin, Wenjing Geng, Qiuhu Shi, Divya Balasubramanian, Christine J Kubin, Victor J Torres, Anne-Catrin Uhlemann

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Thomas H McConville *Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
Eloise D Austin *Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
Wenjing GengDepartment of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
Qiuhu ShiBiostatistics, Department of Epidemiology, New York Medical Collegegrid.260917.b, New York, New York, USA.
Divya BalasubramanianDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Christine J KubinDepartment of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-9819-440X
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Anne-Catrin UhlemannDepartment of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-9798-4768
Columbia University Irving Medical Center · USNew York University · USNew York Medical College · USNewYork–Presbyterian Hospital · US

Funding

Mechanistic Studies Of The Staphylococcus aureus LukAB CytotoxinR01AI099394 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Victor J. Torres · 2013 to 2026
$6.1M
Contribution of LukED to Staphylococcus aureus pathobiologyR01AI105129 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TORRES, VICTOR J. · 2014 to 2023
$4.9M
Host-pathogen interactions during hospital adaptation of MRSAR01AI137336 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO, YANAI, ITAI · 2019 to 2022
$3.3M
Columbia Integrated Training Program in Infectious Diseases ResearchT32AI100852 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAGDALENA ELZBIETA SOBIESZCZYK, Anne-Catrin Uhlemann · 2013 to 2026
$2.2M
Mechanisms of S. aureus transmission and persistence.K08AI090013 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2010 to 2014
$655k
The Molecular Epidemiology of Staphylococcus aureus Bacteremias During the Opioid Epidemic: A New York Region PerspectiveR21AI152046 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UHLEMANN, ANNE-CATRIN · 2020 to 2021
$420k
NIAID NIH HHS K08 AI090013NIAID NIH HHS R01 AI099394NIAID NIH HHS R01 AI105129NIAID NIH HHS R01 AI137336NIAID NIH HHS R21 AI152046NIAID NIH HHS T32 AI100852
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections are associated with significant morbidity and mortality. MRSA secretes a number of virulence factors and pore-forming toxins that enable tissue invasion. Prior studies have found associations between decreased toxin production and poor outcomes in invasive MRSA infection, particularly in pneumonia. In this retrospective observational cohort study of MRSA bacteremia in adult patients from 2007 to 2015, we examined whether cytotoxicity was associated with 30-day mortality. Isolates were obtained from 776 patients and screened for cytotoxicity in a human HL-60 cell model, antimicrobial susceptibility, and

Indexed as

BacteremiaMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsRetrospective StudiesVirulence FactorsAnti-Bacterial AgentsVirulence FactorscytotoxicitymortalityMRSAStaphylococcus aureusvirulence

Identifiers

PMID34748383
PMCPMC8765464
OpenAlexW3213046504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.