Evidence map›Paper›PMID 34748116›Full record

ArticleEuropean journal of epidemiology2022

Long-term intake of total energy and fat in relation to subjective cognitive decline.

Tian-Shin Yeh, Changzheng Yuan, Alberto Ascherio, Bernard A Rosner, Deborah Blacker, Walter C Willett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Tian-Shin YehDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Changzheng YuanChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Alberto AscherioDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Bernard A RosnerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Deborah BlackerDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Walter C WillettDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA. wwillett@hsph.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USUniversity of Oxford · GB

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Statistical Analysis and ProgrammingU19CA055075 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2010 to 2011
$8.4M
NCI NIH HHS U01 CA167552NCI NIH HHS U19 CA055075NCI NIH HHS UM1 CA186107NIH HHS U01 167552NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Diet is one of the modifiable risk factors for cognitive decline. However, human studies on total energy intake and cognitive function have remained limited and studies on fat intake and cognitive decline have been inconclusive. We aimed to examine prospectively the associations between long-term intakes of total energy and fat with subsequent subjective cognitive decline (SCD). A total of 49,493 women from the Nurses' Health Study and 27,842 men from the Health Professionals Follow-up Study were followed for over 20 years. Average dietary intake was calculated based on repeated food frequency questionnaires (SFFQs), and Poisson regression was used to evaluate associations. Higher total energy intake was significantly associated with greater odds of SCD in both cohorts. Comparing the highest with lowest quintiles of total energy intake, the pooled multivariable-adjusted ORs (95% CIs) for a 3-unit increment in SCD, corresponding to poor versus normal SCD, was 2.77 (2.53, 2.94). Each 500 kcal/day greater intake of total energy was associated with 48% higher odds of SCD. Intakes of both total fat and total carbohydrate appeared to contribute to the positive association between total energy intake and SCD although for the same percent of energy, the association was stronger for total fat. In conclusion, higher intakes of total energy, total fat, and total carbohydrate were adversely associated with SCD. Whether these associations are causal is unclear and deserves further investigation.

Indexed as

Cognitive DysfunctionDietDietary FatsEatingEnergy IntakeFemaleFollow-Up StudiesHumansMaleRisk FactorsSurveys and QuestionnairesDietary FatsCalorie intakeCognitive functionCohort studyFat intakeSubjective cognitive declineTotal energy

Identifiers

PMID34748116
PMCPMC8960333
OpenAlexW3214134884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.