ArticleApplied microbiology and biotechnology2021
New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation.
Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Novel production of vinblastine by immobilized cultures of mutant strain of the endophytic Alternaria alternata.World journal of microbiology & biotechnology · 2026Article
- Natural pigments from the endophyte Aspergillus westerdijkiae and evaluation of their bioactivities.Microbial cell factories · 2025Article
- Enhanced myco-synthesis of selenium and zinc oxide nanoparticles and evaluating their anticancer activities and role against antibiotic resistance genes in certain bacterial strains.Microbial cell factories · 2025Article
- Fusarium verticillioides pigment: production, response surface optimization, gamma irradiation and encapsulation studies.BMC biotechnology · 2024Article
- Enhancement of paclitaxel production by Neopestalotiopsis vitis via optimization of growth conditions.PloS one · 2024Article
- Article
- Gamma irradiation mediated production improvement of some myco-fabricated nanoparticles and exploring their wound healing, anti-inflammatory and acetylcholinesterase inhibitory potentials.Scientific reports · 2023Article
- Bioprospecting endophytic fungi for antifeedants and larvicides and their enhancement by gamma irradiation.AMB Express · 2022Article
- Improving carboxymethyl cellulose edible coating using ZnO nanoparticles from irradiated Alternaria tenuissima.AMB Express · 2022Article
- A new endophyte Monascus ruber SRZ112 as an efficient production platform of natural pigments using agro-industrial wastes.Scientific reports · 2022Article
- Bioprospecting endophytic fungi for bioactive metabolites and use of irradiation to improve their bioactivities.AMB Express · 2022Article
- Exploiting the exceptional biosynthetic potency of the endophyticSaudi journal of biological sciences · 2022Article
- Novel fabrication of SiOAMB Express · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Huperzine-A (HupA) is an emerging, powerful, and promising natural acetylcholinesterase inhibitor. Despite that, the achieved yields of HupA from microbial sources are still far from the industrial applications. Accordingly, this paper was conducted to valorize solid-state fermentation (SSF) as an efficient production platform of HupA. Four agro-industrial wastes, namely rice bran, potato peel, sugarcane bagasse, and wheat bran, were tested and screened as cultural substrates for the production of HupA by the endophytic Alternaria brassica under SSF. Maximum HupA production was attained on using rice bran moistened by Czapex's dox mineral broth. In the effort to increase the HupA titer, supplementation of the best moistening agent by different carbon and nitrogen sources was successfully investigated. Additionally, factors affecting HupA production under SSF including substrate concentration, moistening level, and inoculum concentration were optimized using response surface methodology. A Box-Behnken design was applied for generating a predictive model of the interactions between these factors. Under the optimum conditions of 15 g rice bran, inoculum concentration of 5 × 10
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