Evidence map›Paper›PMID 34747727›Full record

ReviewAsian journal of andrology

The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis.

Yong-Hong Man, Isabella Warmbrunn, Ling Zhang, Zhi-Bing Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Yong-Hong ManDepartment of Occupational and Environmental Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Isabella WarmbrunnDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Ling ZhangDepartment of Occupational and Environmental Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Zhi-Bing ZhangDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Wayne State University · USNanyang Medical College · CNWuhan University of Science and Technology · CN

Funding

Dissection of the Structural Basis of MEIG1 in Assembling Sperm FlagellaR01HD076257 · NICHD · WAYNE STATE UNIVERSITY · PI ZHANG, ZHIBING · 2013 to 2017
$1.5M
NICHD NIH HHS R01 HD076257
6 · The paper itself

Abstract

Cilium, an organelle with a unique proteome and organization, protruding from the cell surface, generally serves as a force generator and signaling compartment. During ciliogenesis, ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport (IFT) particles, where the inner counterparts undergo reverse trafficking. The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction. Much progress has been made on the mechanisms and functions of IFT; however, recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis. In this review, we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.

Indexed as

Carrier ProteinsCiliaAnimalsBiological TransportFlagellaMaleMammalsOrganogenesisProteinsSignal TransductionCarrier ProteinsProteinsciliumhedgehog signalingIFT25intraflagellar transportspermatogenesis

Identifiers

PMID34747727
PMCPMC9226691
OpenAlexW3209840521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.