Evidence map›Paper›PMID 34747522›Full record

ArticleJournal of neuroscience research2021

Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system x

Sheila M S Sears, Sarah H Roberts, Sandra J Hewett

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Sex- and age-dependent contribution of System xFrontiers in behavioral neuroscience · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sheila M S SearsDepartment of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York, USA.
Sarah H RobertsDepartment of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York, USA.
Sandra J HewettDepartment of Biology, Program in Neuroscience, Syracuse University, Syracuse, New York, USA.
Syracuse University · US

Funding

IL-1 in Protection and InjuryR01NS051445 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HEWETT, SANDRA J · 2006 to 2017
$3.2M
Investigating the Role of System xc- in Glutamate, Glutathione and Synapse Homeostasis in VivoR01NS105767 · NINDS · SYRACUSE UNIVERSITY · PI HEWETT, SANDRA J · 2018 to 2022
$1.9M
NINDS NIH HHS R01 NS051445NINDS NIH HHS R01 NS105767
6 · The paper itself

Abstract

System x

Indexed as

Amino Acid Transport System y+CystineGlutamic AcidAnimalsAntiportersBrainFemaleMaleMiceAmino Acid Transport System y+AntiportersCystineGlutamic AcidSlc7a11 protein, mouseexcitatory/inhibitory balanceRRID: SCR_003070SLC7A11xCT

Identifiers

PMID34747522
PMCPMC8712388
OpenAlexW3211867223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.