Evidence map›Paper›PMID 34747395›Full record

ArticleJournal of visualized experiments : JoVE2021

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing.

Hongkai Wang, Dom D'Andrea, Yeon Sik Choi, Yasmine Bouricha, Grace Wickerson, Hak-Young Ahn, Hexia Guo, Yonggang Huang, Milap S Sandhu, Sumanas W Jordan and 2 more

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongkai WangLaboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; Northwestern University Interdepartmental Neuroscience Program.
Dom D'AndreaLaboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine.
Yeon Sik ChoiCenter for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University; Department of Materials Science and Engineering, Northwestern University.
Yasmine BourichaLaboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine.
Grace WickersonCenter for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University; Department of Materials Science and Engineering, Northwestern University.
Hak-Young AhnCenter for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University.
Hexia GuoCenter for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University; Department of Materials Science and Engineering, Northwestern University.
Yonggang HuangCenter for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University; Department of Materials Science and Engineering, Northwestern University; Department of Civil and Environmental Engineering, Northwestern University; Department of Mechanical Engineering, Northwestern University.
Milap S SandhuArms and Hands Lab, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine.
Sumanas W JordanDivision of Plastic and Reconstructive Surgery, Biologics, Shirley Ryan AbilityLab, Northwestern University.
John A RogersCenter for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University; Department of Materials Science and Engineering, Northwestern University; Department of Mechanical Engineering, Northwestern University; Department of Biomedical Engineering, Northwestern University; Department of Neurological Surgery, Northwestern University; Department of Chemistry, Northwestern University; Department of Electrical and Computer Engineering, Northwestern University.
Colin K FranzLaboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; Center for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University; The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine; cfranz@sralab.org.

Funding

Accelerating nerve regeneration with botulinum toxin and electrical stimulation therapiesR03HD101090 · NICHD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI FRANZ, COLIN · 2021 to 2022
$339k
NICHD NIH HHS R03 HD101090
6 · The paper itself

Abstract

Peripheral nerve interfaces are frequently used in experimental neuroscience and regenerative medicine for a wide variety of applications. Such interfaces can be sensors, actuators, or both. Traditional methods of peripheral nerve interfacing must either tether to an external system or rely on battery power that limits the time frame for operation. With recent developments of wireless, battery-free, and fully implantable peripheral nerve interfaces, a new class of devices can offer capabilities that match or exceed those of their wired or battery-powered precursors. This paper describes methods to (i) surgically implant and (ii) wirelessly power and control this system in adult rats. The sciatic and phrenic nerve models were selected as examples to highlight the versatility of this approach. The paper shows how the peripheral nerve interface can evoke compound muscle action potentials (CMAPs), deliver a therapeutic electrical stimulation protocol, and incorporate a conduit for the repair of peripheral nerve injury. Such devices offer expanded treatment options for single-dose or repeated dose therapeutic stimulation and can be adapted to a variety of nerve locations.

Indexed as

Electric Stimulation TherapyPeripheral NervesAnimalsElectric Power SuppliesPhrenic NerveProstheses and ImplantsRatsWireless Technology

Identifiers

PMID34747395
PMCPMC8981963

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.