Evidence map›Paper›PMID 34747312›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2022

Pregnancy outcomes and anxiety in nulliparous women.

Lauren A Gimbel, Nathan R Blue, Amanda A Allshouse, Robert M Silver, Bruce Gimbel, William A Grobman, David M Haas, Hyagriv N Simhan, Brian M Mercer, Tamera Hatfield

Abstract read
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Maternal stress and fetoplacental cortisol regulation in small-for-gestational-age newborns.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lauren A GimbelObstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.ORCID 0000-0002-0643-4171
Nathan R BlueObstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.
Amanda A AllshouseObstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.
Robert M SilverObstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.
Bruce GimbelPsychiatry, Saint Mary Mercy Hospital, Livonia, MI, USA.
William A GrobmanObstetrics and Gynecology, Northwestern University, Evanston, IL, USA.
David M HaasObstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hyagriv N SimhanObstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Brian M MercerObstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH, USA.
Tamera HatfieldObstetrics and Gynecology, University of California Irvine College of Health Sciences, Irvine, CA, USA.

Funding

NICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD087230 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HYAGRIV N SIMHAN · 2016 to 2026
$3.2M
Utah Women's Reproductive Health Research Career Development ProgramK12HD085816 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2015 to 2024
$3.2M
Prevention of Preterm Birth in high Risk Nulliparous PatientsU10HD063047 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2010 to 2014
$1.9M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063053 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2010 to 2014
$1.7M
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk U10HD063020 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063046 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WING, DEBORAH A · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063041 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SIMHAN, HYAGRIV N · 2010 to 2014
$1.5M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063048 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI PARRY, SAMUEL I. · 2010 to 2014
$1.5M
Utah Stimulating Access to Research in Residency Transition Scholar (StARRTS)R38HL143605 · NHLBI · UNIVERSITY OF UTAH · PI CONROY, MARGARET B, OKUYEMI, KOLAWOLE S · 2018 to 2021
$1.3M
Dissecting the Genetic Etiology of Preterm Birth in Nulliparous WomenU10HD063037 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2010 to 2014
$1.2M
Adverse Outcomes in Nulliparous Pregnancies: The Ohio CollaborativeU10HD063072 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI MERCER, BRIAN M. · 2010 to 2014
$1.2M
NHLBI NIH HHS R38 HL143605NICHD NIH HHS K12 HD085816NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063041NICHD NIH HHS U10 HD063046NICHD NIH HHS U10 HD063047NICHD NIH HHS U10 HD063048NICHD NIH HHS U10 HD063053NICHD NIH HHS U10 HD063072NICHD NIH HHS UG1 HD087230
6 · The paper itself

Abstract

objectiveTo examine pregnancy outcomes in women with treated and untreated anxiety in a well-characterized cohort. STUDY

designSecondary analysis of the NuMoM2b study, a prospective multi-center cohort of nulliparous women. Anxiety was assessed at 6 weeks 0 days - 13 weeks 6 days using the State Trait Anxiety Inventory (STAI-T). Women were divided into three groups: anxiety and medical treatment, anxiety and no medical treatment, and no anxiety (controls). The primary outcome was a composite of preterm birth, small for gestational age infant, placental abruption (clinically diagnosed), and hypertensive disorders of pregnancy. Multivariable logistic regression was used to adjust for potential confounding variables.

resultsAmong 8293 eligible women, 24% (

conclusionAnxiety occurred in almost a quarter of nulliparas. There was no association between treated or untreated anxiety and our primary outcome of adverse pregnancy outcomes after adjustment for confounders. However, neonates born to women with untreated anxiety were at increased risk for NICU admission.

Indexed as

Abruptio PlacentaeHypertension, Pregnancy-InducedPremature BirthFemaleHumansInfantInfant, NewbornPlacentaPregnancyPregnancy OutcomeProspective StudiesanxietyanxiolyticsMaternal mental healthmedicationperinatal mental healthpregnancypregnancy outcomes

Identifiers

PMID34747312
PMCPMC9097789

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.